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Aptamer‐Based Cancer Cell Analysis and Treatment

Aptamers are a class of single‐stranded DNA or RNA oligonucleotides that can exclusively bind to various targets with high affinity and selectivity. Regarded as “chemical antibodies”, aptamers possess several intrinsic advantages, including easy synthesis, convenient modification, high programmabili...

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Detalles Bibliográficos
Autores principales: Wu, Limei, Zhang, Yutong, Wang, Zhimin, Zhang, Yue, Zou, Jianmei, Qiu, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583543/
https://www.ncbi.nlm.nih.gov/pubmed/36264016
http://dx.doi.org/10.1002/open.202200141
Descripción
Sumario:Aptamers are a class of single‐stranded DNA or RNA oligonucleotides that can exclusively bind to various targets with high affinity and selectivity. Regarded as “chemical antibodies”, aptamers possess several intrinsic advantages, including easy synthesis, convenient modification, high programmability, and good biocompatibility. In recent decades, many studies have demonstrated the superiority of aptamers as molecular tools for various biological applications, particularly in the area of cancer theranostics. In this review, we focus on recent progress in developing aptamer‐based strategies for the precise analysis and treatment of cancer cells.