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A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model

The coronavirus pandemic was a global health crisis taking away millions of lives worldwide. People diseased by the virus, differ in the extent of severity of the infection. While it turns out to be fatal for some, for several others the extent of severity is as ordinary as common cold. These people...

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Autores principales: Das, Dhruba, Saikia, Hemanta, Bora, Dibyajyoti, Bhattacharjee, Dibyojyoti, Das, Jondeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583648/
http://dx.doi.org/10.1016/j.dajour.2022.100137
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author Das, Dhruba
Saikia, Hemanta
Bora, Dibyajyoti
Bhattacharjee, Dibyojyoti
Das, Jondeep
author_facet Das, Dhruba
Saikia, Hemanta
Bora, Dibyajyoti
Bhattacharjee, Dibyojyoti
Das, Jondeep
author_sort Das, Dhruba
collection PubMed
description The coronavirus pandemic was a global health crisis taking away millions of lives worldwide. People diseased by the virus, differ in the extent of severity of the infection. While it turns out to be fatal for some, for several others the extent of severity is as ordinary as common cold. These people are reported to have recovered from the disease without hospitalization and consuming some relevant medicine and home remedies. But people who have comorbidity like geriatric, high blood pressure, heart and lung problems, diabetes, cancer etc. are at high risk of developing serious illness from the infection. This study is an application of the Cox proportional hazard model with an aim to identify the risk factors that affect the recovery time of the COVID-19 patients. The model is an advanced regression technique that can be utilized to evaluate simultaneously the effect of several factors on the possibility of instantaneous failure in patients. The paper also uses the Mantel-Haenszel test (Log-Rank test) to compare if the probability of survival of different treatment procedures or different groups of patients differ significantly. The information is collected from 129 respondents of Assam, India. The study identifies that the significant risk factors that prolong the recovery time from COVID-19 are pre-disease, location, and food habits.
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spelling pubmed-95836482022-10-20 A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model Das, Dhruba Saikia, Hemanta Bora, Dibyajyoti Bhattacharjee, Dibyojyoti Das, Jondeep Decision Analytics Journal Article The coronavirus pandemic was a global health crisis taking away millions of lives worldwide. People diseased by the virus, differ in the extent of severity of the infection. While it turns out to be fatal for some, for several others the extent of severity is as ordinary as common cold. These people are reported to have recovered from the disease without hospitalization and consuming some relevant medicine and home remedies. But people who have comorbidity like geriatric, high blood pressure, heart and lung problems, diabetes, cancer etc. are at high risk of developing serious illness from the infection. This study is an application of the Cox proportional hazard model with an aim to identify the risk factors that affect the recovery time of the COVID-19 patients. The model is an advanced regression technique that can be utilized to evaluate simultaneously the effect of several factors on the possibility of instantaneous failure in patients. The paper also uses the Mantel-Haenszel test (Log-Rank test) to compare if the probability of survival of different treatment procedures or different groups of patients differ significantly. The information is collected from 129 respondents of Assam, India. The study identifies that the significant risk factors that prolong the recovery time from COVID-19 are pre-disease, location, and food habits. The Author(s). Published by Elsevier Inc. 2022-12 2022-10-20 /pmc/articles/PMC9583648/ http://dx.doi.org/10.1016/j.dajour.2022.100137 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Das, Dhruba
Saikia, Hemanta
Bora, Dibyajyoti
Bhattacharjee, Dibyojyoti
Das, Jondeep
A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model
title A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model
title_full A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model
title_fullStr A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model
title_full_unstemmed A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model
title_short A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model
title_sort survival analysis approach for identifying the risk factors in time to recovery of covid-19 patients using cox proportional hazard model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583648/
http://dx.doi.org/10.1016/j.dajour.2022.100137
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