Cargando…
Immune and inflammatory mechanisms of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-mediated infiltration and a destruction of the aortic wall during AAA development plays significant role in the pathogenesis of this disease. While various immune cells had been found in AAA, the mechanisms of their...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583679/ https://www.ncbi.nlm.nih.gov/pubmed/36275758 http://dx.doi.org/10.3389/fimmu.2022.989933 |
_version_ | 1784813126083936256 |
---|---|
author | Márquez-Sánchez, Ana Cristina Koltsova, Ekaterina K. |
author_facet | Márquez-Sánchez, Ana Cristina Koltsova, Ekaterina K. |
author_sort | Márquez-Sánchez, Ana Cristina |
collection | PubMed |
description | Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-mediated infiltration and a destruction of the aortic wall during AAA development plays significant role in the pathogenesis of this disease. While various immune cells had been found in AAA, the mechanisms of their activation and function are still far from being understood. A better understanding of mechanisms regulating the development of aberrant immune cell activation in AAA is essential for the development of novel preventive and therapeutic approaches. In this review we summarize current knowledge about the role of immune cells in AAA and discuss how pathogenic immune cell activation is regulated in this disease. |
format | Online Article Text |
id | pubmed-9583679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95836792022-10-21 Immune and inflammatory mechanisms of abdominal aortic aneurysm Márquez-Sánchez, Ana Cristina Koltsova, Ekaterina K. Front Immunol Immunology Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-mediated infiltration and a destruction of the aortic wall during AAA development plays significant role in the pathogenesis of this disease. While various immune cells had been found in AAA, the mechanisms of their activation and function are still far from being understood. A better understanding of mechanisms regulating the development of aberrant immune cell activation in AAA is essential for the development of novel preventive and therapeutic approaches. In this review we summarize current knowledge about the role of immune cells in AAA and discuss how pathogenic immune cell activation is regulated in this disease. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9583679/ /pubmed/36275758 http://dx.doi.org/10.3389/fimmu.2022.989933 Text en Copyright © 2022 Márquez-Sánchez and Koltsova https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Márquez-Sánchez, Ana Cristina Koltsova, Ekaterina K. Immune and inflammatory mechanisms of abdominal aortic aneurysm |
title | Immune and inflammatory mechanisms of abdominal aortic aneurysm |
title_full | Immune and inflammatory mechanisms of abdominal aortic aneurysm |
title_fullStr | Immune and inflammatory mechanisms of abdominal aortic aneurysm |
title_full_unstemmed | Immune and inflammatory mechanisms of abdominal aortic aneurysm |
title_short | Immune and inflammatory mechanisms of abdominal aortic aneurysm |
title_sort | immune and inflammatory mechanisms of abdominal aortic aneurysm |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583679/ https://www.ncbi.nlm.nih.gov/pubmed/36275758 http://dx.doi.org/10.3389/fimmu.2022.989933 |
work_keys_str_mv | AT marquezsanchezanacristina immuneandinflammatorymechanismsofabdominalaorticaneurysm AT koltsovaekaterinak immuneandinflammatorymechanismsofabdominalaorticaneurysm |