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Dopamine activity on the perceptual salience for recognition memory

To survive, animals must recognize relevant stimuli and distinguish them from inconspicuous information. Usually, the properties of the stimuli, such as intensity, duration, frequency, and novelty, among others, determine the salience of the stimulus. However, previously learned experiences also fac...

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Autores principales: Osorio-Gómez, Daniel, Guzmán-Ramos, Kioko, Bermúdez-Rattoni, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583835/
https://www.ncbi.nlm.nih.gov/pubmed/36275849
http://dx.doi.org/10.3389/fnbeh.2022.963739
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author Osorio-Gómez, Daniel
Guzmán-Ramos, Kioko
Bermúdez-Rattoni, Federico
author_facet Osorio-Gómez, Daniel
Guzmán-Ramos, Kioko
Bermúdez-Rattoni, Federico
author_sort Osorio-Gómez, Daniel
collection PubMed
description To survive, animals must recognize relevant stimuli and distinguish them from inconspicuous information. Usually, the properties of the stimuli, such as intensity, duration, frequency, and novelty, among others, determine the salience of the stimulus. However, previously learned experiences also facilitate the perception and processing of information to establish their salience. Here, we propose “perceptual salience” to define how memory mediates the integration of inconspicuous stimuli into a relevant memory trace without apparently altering the recognition of the physical attributes or valence, enabling the detection of stimuli changes in future encounters. The sense of familiarity is essential for successful recognition memory; in general, familiarization allows the transition of labeling a stimulus from the novel (salient) to the familiar (non-salient). The novel object recognition (NOR) and object location recognition (OLRM) memory paradigms represent experimental models of recognition memory that allow us to study the neurobiological mechanisms involved in episodic memory. The catecholaminergic system has been of vital interest due to its role in several aspects of recognition memory. This review will discuss the evidence that indicates changes in dopaminergic activity during exposure to novel objects or places, promoting the consolidation and persistence of memory. We will discuss the relationship between dopaminergic activity and perceptual salience of stimuli enabling learning and consolidation processes necessary for the novel-familiar transition. Finally, we will describe the effect of dopaminergic deregulation observed in some pathologies and its impact on recognition memory.
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spelling pubmed-95838352022-10-21 Dopamine activity on the perceptual salience for recognition memory Osorio-Gómez, Daniel Guzmán-Ramos, Kioko Bermúdez-Rattoni, Federico Front Behav Neurosci Behavioral Neuroscience To survive, animals must recognize relevant stimuli and distinguish them from inconspicuous information. Usually, the properties of the stimuli, such as intensity, duration, frequency, and novelty, among others, determine the salience of the stimulus. However, previously learned experiences also facilitate the perception and processing of information to establish their salience. Here, we propose “perceptual salience” to define how memory mediates the integration of inconspicuous stimuli into a relevant memory trace without apparently altering the recognition of the physical attributes or valence, enabling the detection of stimuli changes in future encounters. The sense of familiarity is essential for successful recognition memory; in general, familiarization allows the transition of labeling a stimulus from the novel (salient) to the familiar (non-salient). The novel object recognition (NOR) and object location recognition (OLRM) memory paradigms represent experimental models of recognition memory that allow us to study the neurobiological mechanisms involved in episodic memory. The catecholaminergic system has been of vital interest due to its role in several aspects of recognition memory. This review will discuss the evidence that indicates changes in dopaminergic activity during exposure to novel objects or places, promoting the consolidation and persistence of memory. We will discuss the relationship between dopaminergic activity and perceptual salience of stimuli enabling learning and consolidation processes necessary for the novel-familiar transition. Finally, we will describe the effect of dopaminergic deregulation observed in some pathologies and its impact on recognition memory. Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9583835/ /pubmed/36275849 http://dx.doi.org/10.3389/fnbeh.2022.963739 Text en Copyright © 2022 Osorio-Gómez, Guzmán-Ramos and Bermúdez-Rattoni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Osorio-Gómez, Daniel
Guzmán-Ramos, Kioko
Bermúdez-Rattoni, Federico
Dopamine activity on the perceptual salience for recognition memory
title Dopamine activity on the perceptual salience for recognition memory
title_full Dopamine activity on the perceptual salience for recognition memory
title_fullStr Dopamine activity on the perceptual salience for recognition memory
title_full_unstemmed Dopamine activity on the perceptual salience for recognition memory
title_short Dopamine activity on the perceptual salience for recognition memory
title_sort dopamine activity on the perceptual salience for recognition memory
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583835/
https://www.ncbi.nlm.nih.gov/pubmed/36275849
http://dx.doi.org/10.3389/fnbeh.2022.963739
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