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Dopamine activity on the perceptual salience for recognition memory
To survive, animals must recognize relevant stimuli and distinguish them from inconspicuous information. Usually, the properties of the stimuli, such as intensity, duration, frequency, and novelty, among others, determine the salience of the stimulus. However, previously learned experiences also fac...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583835/ https://www.ncbi.nlm.nih.gov/pubmed/36275849 http://dx.doi.org/10.3389/fnbeh.2022.963739 |
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author | Osorio-Gómez, Daniel Guzmán-Ramos, Kioko Bermúdez-Rattoni, Federico |
author_facet | Osorio-Gómez, Daniel Guzmán-Ramos, Kioko Bermúdez-Rattoni, Federico |
author_sort | Osorio-Gómez, Daniel |
collection | PubMed |
description | To survive, animals must recognize relevant stimuli and distinguish them from inconspicuous information. Usually, the properties of the stimuli, such as intensity, duration, frequency, and novelty, among others, determine the salience of the stimulus. However, previously learned experiences also facilitate the perception and processing of information to establish their salience. Here, we propose “perceptual salience” to define how memory mediates the integration of inconspicuous stimuli into a relevant memory trace without apparently altering the recognition of the physical attributes or valence, enabling the detection of stimuli changes in future encounters. The sense of familiarity is essential for successful recognition memory; in general, familiarization allows the transition of labeling a stimulus from the novel (salient) to the familiar (non-salient). The novel object recognition (NOR) and object location recognition (OLRM) memory paradigms represent experimental models of recognition memory that allow us to study the neurobiological mechanisms involved in episodic memory. The catecholaminergic system has been of vital interest due to its role in several aspects of recognition memory. This review will discuss the evidence that indicates changes in dopaminergic activity during exposure to novel objects or places, promoting the consolidation and persistence of memory. We will discuss the relationship between dopaminergic activity and perceptual salience of stimuli enabling learning and consolidation processes necessary for the novel-familiar transition. Finally, we will describe the effect of dopaminergic deregulation observed in some pathologies and its impact on recognition memory. |
format | Online Article Text |
id | pubmed-9583835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95838352022-10-21 Dopamine activity on the perceptual salience for recognition memory Osorio-Gómez, Daniel Guzmán-Ramos, Kioko Bermúdez-Rattoni, Federico Front Behav Neurosci Behavioral Neuroscience To survive, animals must recognize relevant stimuli and distinguish them from inconspicuous information. Usually, the properties of the stimuli, such as intensity, duration, frequency, and novelty, among others, determine the salience of the stimulus. However, previously learned experiences also facilitate the perception and processing of information to establish their salience. Here, we propose “perceptual salience” to define how memory mediates the integration of inconspicuous stimuli into a relevant memory trace without apparently altering the recognition of the physical attributes or valence, enabling the detection of stimuli changes in future encounters. The sense of familiarity is essential for successful recognition memory; in general, familiarization allows the transition of labeling a stimulus from the novel (salient) to the familiar (non-salient). The novel object recognition (NOR) and object location recognition (OLRM) memory paradigms represent experimental models of recognition memory that allow us to study the neurobiological mechanisms involved in episodic memory. The catecholaminergic system has been of vital interest due to its role in several aspects of recognition memory. This review will discuss the evidence that indicates changes in dopaminergic activity during exposure to novel objects or places, promoting the consolidation and persistence of memory. We will discuss the relationship between dopaminergic activity and perceptual salience of stimuli enabling learning and consolidation processes necessary for the novel-familiar transition. Finally, we will describe the effect of dopaminergic deregulation observed in some pathologies and its impact on recognition memory. Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9583835/ /pubmed/36275849 http://dx.doi.org/10.3389/fnbeh.2022.963739 Text en Copyright © 2022 Osorio-Gómez, Guzmán-Ramos and Bermúdez-Rattoni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Behavioral Neuroscience Osorio-Gómez, Daniel Guzmán-Ramos, Kioko Bermúdez-Rattoni, Federico Dopamine activity on the perceptual salience for recognition memory |
title | Dopamine activity on the perceptual salience for recognition memory |
title_full | Dopamine activity on the perceptual salience for recognition memory |
title_fullStr | Dopamine activity on the perceptual salience for recognition memory |
title_full_unstemmed | Dopamine activity on the perceptual salience for recognition memory |
title_short | Dopamine activity on the perceptual salience for recognition memory |
title_sort | dopamine activity on the perceptual salience for recognition memory |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583835/ https://www.ncbi.nlm.nih.gov/pubmed/36275849 http://dx.doi.org/10.3389/fnbeh.2022.963739 |
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