Cargando…

Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance

Human immunodeficiency virus (HIV) and hepatitis-B virus (HBV) infections are weighty public health challenges, especially in the African continent. The direct carcinogenic effect of HBV means that it remains a potent cause of early-onset hepatocellular carcinoma (HCC) in Sub-Saharan Africa (SSA), w...

Descripción completa

Detalles Bibliográficos
Autores principales: Wan, Qian, Anugwom, Chimaobi, Desalegn, Hailemichael, Debes, Jose D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583937/
https://www.ncbi.nlm.nih.gov/pubmed/36277115
http://dx.doi.org/10.20517/2394-5079.2022.32
_version_ 1784813179266662400
author Wan, Qian
Anugwom, Chimaobi
Desalegn, Hailemichael
Debes, Jose D.
author_facet Wan, Qian
Anugwom, Chimaobi
Desalegn, Hailemichael
Debes, Jose D.
author_sort Wan, Qian
collection PubMed
description Human immunodeficiency virus (HIV) and hepatitis-B virus (HBV) infections are weighty public health challenges, especially in the African continent. The direct carcinogenic effect of HBV means that it remains a potent cause of early-onset hepatocellular carcinoma (HCC) in Sub-Saharan Africa (SSA), where it causes significant morbidity and mortality. The presence of HIV infection in HBV-infected patients poses a complicating factor, as coinfection has been shown to hasten the progression of liver disease to cirrhosis and HCC, and often resulting in early-age hepatocarcinogenesis with consequent late diagnosis and lower survival. In this review, we discuss this unique conundrum, the epidemiology of HIV-HBV coinfection in SSA, its effect on liver disease and development of HCC, as well as practices and barriers to HCC surveillance in this distinct population. We propose a way forward to curb this considerable health burden focusing on reduction of disease stigma, the need for easy-to-measure biomarkers, and implementation of large prospective studies in this population.
format Online
Article
Text
id pubmed-9583937
institution National Center for Biotechnology Information
language English
publishDate 2022
record_format MEDLINE/PubMed
spelling pubmed-95839372022-10-20 Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance Wan, Qian Anugwom, Chimaobi Desalegn, Hailemichael Debes, Jose D. Hepatoma Res Article Human immunodeficiency virus (HIV) and hepatitis-B virus (HBV) infections are weighty public health challenges, especially in the African continent. The direct carcinogenic effect of HBV means that it remains a potent cause of early-onset hepatocellular carcinoma (HCC) in Sub-Saharan Africa (SSA), where it causes significant morbidity and mortality. The presence of HIV infection in HBV-infected patients poses a complicating factor, as coinfection has been shown to hasten the progression of liver disease to cirrhosis and HCC, and often resulting in early-age hepatocarcinogenesis with consequent late diagnosis and lower survival. In this review, we discuss this unique conundrum, the epidemiology of HIV-HBV coinfection in SSA, its effect on liver disease and development of HCC, as well as practices and barriers to HCC surveillance in this distinct population. We propose a way forward to curb this considerable health burden focusing on reduction of disease stigma, the need for easy-to-measure biomarkers, and implementation of large prospective studies in this population. 2022 2022-10-14 /pmc/articles/PMC9583937/ /pubmed/36277115 http://dx.doi.org/10.20517/2394-5079.2022.32 Text en https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Wan, Qian
Anugwom, Chimaobi
Desalegn, Hailemichael
Debes, Jose D.
Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance
title Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance
title_full Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance
title_fullStr Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance
title_full_unstemmed Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance
title_short Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance
title_sort hepatocellular carcinoma in hepatitis b and human immunodeficiency virus coinfection in africa: a focus on surveillance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583937/
https://www.ncbi.nlm.nih.gov/pubmed/36277115
http://dx.doi.org/10.20517/2394-5079.2022.32
work_keys_str_mv AT wanqian hepatocellularcarcinomainhepatitisbandhumanimmunodeficiencyviruscoinfectioninafricaafocusonsurveillance
AT anugwomchimaobi hepatocellularcarcinomainhepatitisbandhumanimmunodeficiencyviruscoinfectioninafricaafocusonsurveillance
AT desalegnhailemichael hepatocellularcarcinomainhepatitisbandhumanimmunodeficiencyviruscoinfectioninafricaafocusonsurveillance
AT debesjosed hepatocellularcarcinomainhepatitisbandhumanimmunodeficiencyviruscoinfectioninafricaafocusonsurveillance