Cargando…
ASSESSMENTS OF MACULAR FUNCTION BY FOCAL MACULAR ELECTRORETINOGRAPHY AND STATIC PERIMETRY IN EYES WITH RETINITIS PIGMENTOSA
To assess the macular function by focal macular electroretinography and static perimetry in eyes with retinitis pigmentosa. METHODS: Eighty-eight eyes of 88 retinitis pigmentosa patients were analyzed. The relationships between the focal macular electroretinography components and the mean deviations...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Retina
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584050/ https://www.ncbi.nlm.nih.gov/pubmed/35982511 http://dx.doi.org/10.1097/IAE.0000000000003589 |
_version_ | 1784813193291366400 |
---|---|
author | Okado, Satoshi Koyanagi, Yoshito Inooka, Taiga Kominami, Taro Terasaki, Hiroko Nishiguchi, Koji M. Ueno, Shinji |
author_facet | Okado, Satoshi Koyanagi, Yoshito Inooka, Taiga Kominami, Taro Terasaki, Hiroko Nishiguchi, Koji M. Ueno, Shinji |
author_sort | Okado, Satoshi |
collection | PubMed |
description | To assess the macular function by focal macular electroretinography and static perimetry in eyes with retinitis pigmentosa. METHODS: Eighty-eight eyes of 88 retinitis pigmentosa patients were analyzed. The relationships between the focal macular electroretinography components and the mean deviations (MDs) of the Humphrey Field Analyzer 10-2 were determined. Spectral-domain optical coherence tomography was used to determine the integrity of the ellipsoid zone (EZ) and the interdigitation zone. RESULTS: Forward–backward stepwise regression analyses showed that the amplitudes (r = 0.45, P < 0.01) and implicit times (r = −0.29, P < 0.01) of the b-waves were significantly correlated with the MDs. Some of the eyes had reduced b-wave amplitudes (<1.0 µV) and disrupted interdigitation zone, despite having a better MD (≥ −10.0 dB) and intact EZ. Subgroup analyses of eyes with better MD (≥ −10.0 dB) showed that the EZ width was correlated with the MDs but not with the b-wave amplitude. The thickness of the EZ–retinal pigment epithelium as an alternative indicator of interdigitation zone was correlated with the b-wave amplitude (r = 0.32, P = 0.04) but not with the MDs (r = −0.10, P = 0.53). CONCLUSION: The fact that the focal macular electroretinography amplitudes are reduced before the shortening of the EZ in the early stage of retinitis pigmentosa indicates that the focal macular electroretinography amplitudes are an earlier indicator of macular dysfunction than the Humphrey Field Analyzer 10-2 findings. |
format | Online Article Text |
id | pubmed-9584050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Retina |
record_format | MEDLINE/PubMed |
spelling | pubmed-95840502022-10-27 ASSESSMENTS OF MACULAR FUNCTION BY FOCAL MACULAR ELECTRORETINOGRAPHY AND STATIC PERIMETRY IN EYES WITH RETINITIS PIGMENTOSA Okado, Satoshi Koyanagi, Yoshito Inooka, Taiga Kominami, Taro Terasaki, Hiroko Nishiguchi, Koji M. Ueno, Shinji Retina Original Study To assess the macular function by focal macular electroretinography and static perimetry in eyes with retinitis pigmentosa. METHODS: Eighty-eight eyes of 88 retinitis pigmentosa patients were analyzed. The relationships between the focal macular electroretinography components and the mean deviations (MDs) of the Humphrey Field Analyzer 10-2 were determined. Spectral-domain optical coherence tomography was used to determine the integrity of the ellipsoid zone (EZ) and the interdigitation zone. RESULTS: Forward–backward stepwise regression analyses showed that the amplitudes (r = 0.45, P < 0.01) and implicit times (r = −0.29, P < 0.01) of the b-waves were significantly correlated with the MDs. Some of the eyes had reduced b-wave amplitudes (<1.0 µV) and disrupted interdigitation zone, despite having a better MD (≥ −10.0 dB) and intact EZ. Subgroup analyses of eyes with better MD (≥ −10.0 dB) showed that the EZ width was correlated with the MDs but not with the b-wave amplitude. The thickness of the EZ–retinal pigment epithelium as an alternative indicator of interdigitation zone was correlated with the b-wave amplitude (r = 0.32, P = 0.04) but not with the MDs (r = −0.10, P = 0.53). CONCLUSION: The fact that the focal macular electroretinography amplitudes are reduced before the shortening of the EZ in the early stage of retinitis pigmentosa indicates that the focal macular electroretinography amplitudes are an earlier indicator of macular dysfunction than the Humphrey Field Analyzer 10-2 findings. Retina 2022-11 2022-08-15 /pmc/articles/PMC9584050/ /pubmed/35982511 http://dx.doi.org/10.1097/IAE.0000000000003589 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Original Study Okado, Satoshi Koyanagi, Yoshito Inooka, Taiga Kominami, Taro Terasaki, Hiroko Nishiguchi, Koji M. Ueno, Shinji ASSESSMENTS OF MACULAR FUNCTION BY FOCAL MACULAR ELECTRORETINOGRAPHY AND STATIC PERIMETRY IN EYES WITH RETINITIS PIGMENTOSA |
title | ASSESSMENTS OF MACULAR FUNCTION BY FOCAL MACULAR ELECTRORETINOGRAPHY AND STATIC PERIMETRY IN EYES WITH RETINITIS PIGMENTOSA |
title_full | ASSESSMENTS OF MACULAR FUNCTION BY FOCAL MACULAR ELECTRORETINOGRAPHY AND STATIC PERIMETRY IN EYES WITH RETINITIS PIGMENTOSA |
title_fullStr | ASSESSMENTS OF MACULAR FUNCTION BY FOCAL MACULAR ELECTRORETINOGRAPHY AND STATIC PERIMETRY IN EYES WITH RETINITIS PIGMENTOSA |
title_full_unstemmed | ASSESSMENTS OF MACULAR FUNCTION BY FOCAL MACULAR ELECTRORETINOGRAPHY AND STATIC PERIMETRY IN EYES WITH RETINITIS PIGMENTOSA |
title_short | ASSESSMENTS OF MACULAR FUNCTION BY FOCAL MACULAR ELECTRORETINOGRAPHY AND STATIC PERIMETRY IN EYES WITH RETINITIS PIGMENTOSA |
title_sort | assessments of macular function by focal macular electroretinography and static perimetry in eyes with retinitis pigmentosa |
topic | Original Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584050/ https://www.ncbi.nlm.nih.gov/pubmed/35982511 http://dx.doi.org/10.1097/IAE.0000000000003589 |
work_keys_str_mv | AT okadosatoshi assessmentsofmacularfunctionbyfocalmacularelectroretinographyandstaticperimetryineyeswithretinitispigmentosa AT koyanagiyoshito assessmentsofmacularfunctionbyfocalmacularelectroretinographyandstaticperimetryineyeswithretinitispigmentosa AT inookataiga assessmentsofmacularfunctionbyfocalmacularelectroretinographyandstaticperimetryineyeswithretinitispigmentosa AT kominamitaro assessmentsofmacularfunctionbyfocalmacularelectroretinographyandstaticperimetryineyeswithretinitispigmentosa AT terasakihiroko assessmentsofmacularfunctionbyfocalmacularelectroretinographyandstaticperimetryineyeswithretinitispigmentosa AT nishiguchikojim assessmentsofmacularfunctionbyfocalmacularelectroretinographyandstaticperimetryineyeswithretinitispigmentosa AT uenoshinji assessmentsofmacularfunctionbyfocalmacularelectroretinographyandstaticperimetryineyeswithretinitispigmentosa |