Human-Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy

The Δ160E mutation in TNNT2, which encodes troponin T, is a rare pathogenic variant identified in patients with hypertrophic cardiomyopathy and is associated with poor prognosis. Thus, a convenient human model recapitulating the pathological phenotype caused by TNNT2 Δ160E is required for therapeuti...

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Detalles Bibliográficos
Autores principales: Kondo, Takumi, Higo, Shuichiro, Shiba, Mikio, Kohama, Yasuaki, Kameda, Satoshi, Tabata, Tomoka, Inoue, Hiroyuki, Okuno, Shota, Ogawa, Shou, Nakamura, Satoki, Takeda, Maki, Ito, Emiko, Li, Junjun, Liu, Li, Kuramoto, Yuki, Lee, Jong-Kook, Takashima, Seiji, Miyagawa, Shigeru, Sawa, Yoshiki, Hikoso, Shungo, Sakata, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584061/
https://www.ncbi.nlm.nih.gov/pubmed/35861968
http://dx.doi.org/10.1161/CIRCGEN.121.003522

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