Mineralocorticoid Receptor Pathway Is a Key Mediator of Carfilzomib-induced Nephrotoxicity: Preventive Role of Eplerenone

Carfilzomib is an irreversible proteasome inhibitor indicated for relapsed/refractory multiple myeloma. Carfilzomib toxicity includes renal adverse effects (RAEs) of obscure pathobiology. Therefore, we investigated the mechanisms of nephrotoxicity developed by Carfilzomib. In a first experimental se...

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Detalles Bibliográficos
Autores principales: Efentakis, Panagiotis, Lamprou, Sofia, Makridakis, Manousos, Barla, Ioanna, Nikolaou, Panagiota-Efstathia, Christodoulou, Andriana, Dimitriou, Costantinos, Kostomitsopoulos, Nikolaos, Ntanasis-Stathopoulos, Ioannis, Theochari, Irene, Gavriatopoulou, Maria, Gakiopoulou, Harikleia, Tasouli, Androniki, Vlahou, Antonia, Gikas, Evangelos, Thomaidis, Nikolaos, Dimopoulos, Meletios-Athanasios, Terpos, Evangelos, Andreadou, Ioanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584194/
https://www.ncbi.nlm.nih.gov/pubmed/36285072
http://dx.doi.org/10.1097/HS9.0000000000000791

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