PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far

The Fallopian tube epithelium harbors the origin cells for the majority of high-grade serous ovarian carcinomas (HGSCs), the most lethal form of gynecologic malignancies. PAX8 belongs to the paired-box gene family of transcription factors and it is a marker of the FTE secretory cell lineage. Its rol...

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Detalles Bibliográficos
Autores principales: Di Palma, Tina, Zannini, Mariastella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584354/
https://www.ncbi.nlm.nih.gov/pubmed/36275185
http://dx.doi.org/10.2147/OTT.S361511
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author Di Palma, Tina
Zannini, Mariastella
author_facet Di Palma, Tina
Zannini, Mariastella
author_sort Di Palma, Tina
collection PubMed
description The Fallopian tube epithelium harbors the origin cells for the majority of high-grade serous ovarian carcinomas (HGSCs), the most lethal form of gynecologic malignancies. PAX8 belongs to the paired-box gene family of transcription factors and it is a marker of the FTE secretory cell lineage. Its role has been investigated in migration, invasion, proliferation, cell survival, stem cell maintenance, angiogenesis and tumor growth. In this review, we focus on the pro-tumorigenic role of PAX8 in ovarian cancer; in this context, PAX8 possibly continues to exert its transcriptional activity on its physiological targets but may also function on newly available targets after the tumorigenic hits. Acquiring new insights into the different PAX8 mechanism(s) of action in the tumor microenvironment could uncover new viable therapeutic targets and thus improve the current treatment regimen.
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spelling pubmed-95843542022-10-21 PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far Di Palma, Tina Zannini, Mariastella Onco Targets Ther Review The Fallopian tube epithelium harbors the origin cells for the majority of high-grade serous ovarian carcinomas (HGSCs), the most lethal form of gynecologic malignancies. PAX8 belongs to the paired-box gene family of transcription factors and it is a marker of the FTE secretory cell lineage. Its role has been investigated in migration, invasion, proliferation, cell survival, stem cell maintenance, angiogenesis and tumor growth. In this review, we focus on the pro-tumorigenic role of PAX8 in ovarian cancer; in this context, PAX8 possibly continues to exert its transcriptional activity on its physiological targets but may also function on newly available targets after the tumorigenic hits. Acquiring new insights into the different PAX8 mechanism(s) of action in the tumor microenvironment could uncover new viable therapeutic targets and thus improve the current treatment regimen. Dove 2022-10-21 /pmc/articles/PMC9584354/ /pubmed/36275185 http://dx.doi.org/10.2147/OTT.S361511 Text en © 2022 Di Palma and Zannini. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Di Palma, Tina
Zannini, Mariastella
PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far
title PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far
title_full PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far
title_fullStr PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far
title_full_unstemmed PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far
title_short PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far
title_sort pax8 as a potential target for ovarian cancer: what we know so far
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584354/
https://www.ncbi.nlm.nih.gov/pubmed/36275185
http://dx.doi.org/10.2147/OTT.S361511
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