A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response

Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RFs). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bound by Replication Protein A (RPA) complexes. Such...

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Detalles Bibliográficos
Autores principales: Lemay, Jean-François, St-Hilaire, Edlie, Ronato, Daryl A., Gao, Yuandi, Bélanger, François, Gezzar-Dandashi, Sari, Kimenyi Ishimwe, Aimé Boris, Sawchyn, Christina, Lévesque, Dominique, McQuaid, Mary, Boisvert, François-Michel, Mallette, Frédérick A., Masson, Jean-Yves, Drobetsky, Elliot A., Wurtele, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584372/
https://www.ncbi.nlm.nih.gov/pubmed/36215310
http://dx.doi.org/10.1371/journal.pbio.3001543

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