FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers

In the study of "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers" which was published earlier in Nature Communications, the authors have identified a novel KEAP1/NRF2 target gene, FSP1, and demonstrated that FSP1 plays an essential rol...

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Autores principales: Emmanuel, Nsengiyumva, Li, Hongen, Chen, Jing, Zhang, Yilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584440/
https://www.ncbi.nlm.nih.gov/pubmed/36264074
http://dx.doi.org/10.18632/oncotarget.28301
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author Emmanuel, Nsengiyumva
Li, Hongen
Chen, Jing
Zhang, Yilei
author_facet Emmanuel, Nsengiyumva
Li, Hongen
Chen, Jing
Zhang, Yilei
author_sort Emmanuel, Nsengiyumva
collection PubMed
description In the study of "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers" which was published earlier in Nature Communications, the authors have identified a novel KEAP1/NRF2 target gene, FSP1, and demonstrated that FSP1 plays an essential role in NRF2-mediated ferroptosis resistance and radioresistance in KEAP1-deficient lung cancer cells. Currently, many NRF2 target genes have been found to participate in the regulation of ferroptosis, and exactly which one plays a dominant role seems unclear. This study proposes that FSP1 is the key effector in NRF2-mediated ferroptosis resistance and radioresistance in KEAP-deficient lung cancer cells, as we discussed in the manuscript.
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spelling pubmed-95844402022-10-21 FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers Emmanuel, Nsengiyumva Li, Hongen Chen, Jing Zhang, Yilei Oncotarget Research Perspective In the study of "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers" which was published earlier in Nature Communications, the authors have identified a novel KEAP1/NRF2 target gene, FSP1, and demonstrated that FSP1 plays an essential role in NRF2-mediated ferroptosis resistance and radioresistance in KEAP1-deficient lung cancer cells. Currently, many NRF2 target genes have been found to participate in the regulation of ferroptosis, and exactly which one plays a dominant role seems unclear. This study proposes that FSP1 is the key effector in NRF2-mediated ferroptosis resistance and radioresistance in KEAP-deficient lung cancer cells, as we discussed in the manuscript. Impact Journals LLC 2022-10-19 /pmc/articles/PMC9584440/ /pubmed/36264074 http://dx.doi.org/10.18632/oncotarget.28301 Text en Copyright: © 2022 Emmanuel et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Emmanuel, Nsengiyumva
Li, Hongen
Chen, Jing
Zhang, Yilei
FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
title FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
title_full FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
title_fullStr FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
title_full_unstemmed FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
title_short FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
title_sort fsp1, a novel keap1/nrf2 target gene regulating ferroptosis and radioresistance in lung cancers
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584440/
https://www.ncbi.nlm.nih.gov/pubmed/36264074
http://dx.doi.org/10.18632/oncotarget.28301
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