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Therapeutic efficacy of the humanized JAA-F11 anti-Thomsen-Friedenreich antibody constructs H2aL2a and H3L3 in human breast and lung cancer xenograft models

The Thomsen-Friedenreich antigen (TF-Ag-α) is found on ~85% of human carcinomas but is cryptic on normal tissue. The humanized highly specific hJAA-F11-H2aL2a and -H3L3 antibodies target TF-Ag-α without binding to TF-Ag-beta (found on surface glycolipids of some normal cells). The relative affinity...

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Detalles Bibliográficos
Autores principales:	Ghazal, Diala, Zalzala, Fatma, Fisk, John C., Tati, Swetha, Karacosta, Loukia G., Morey, Susan, Olson, James R., Quataert, Sally, Dy, Grace K., Rittenhouse-Olson, Kate
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584441/ https://www.ncbi.nlm.nih.gov/pubmed/36264086 http://dx.doi.org/10.18632/oncotarget.28282

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