Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry

We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral proteins by human host cell N-myristoyltransferases (NMTs), and is inhibited by treatment with IMP-1088, an ultrapotent small molecule NMT in...

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Detalles Bibliográficos
Autores principales: Priyamvada, Lalita, Kallemeijn, Wouter W., Faronato, Monica, Wilkins, Kimberly, Goldsmith, Cynthia S., Cotter, Catherine A., Ojeda, Suany, Solari, Roberto, Moss, Bernard, Tate, Edward W., Satheshkumar, Panayampalli Subbian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584500/
https://www.ncbi.nlm.nih.gov/pubmed/36215331
http://dx.doi.org/10.1371/journal.ppat.1010662

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