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Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3

The AAA+ protein, Skd3 (human CLPB), solubilizes proteins in the mitochondrial intermembrane space, which is critical for human health. Skd3 variants with defective protein-disaggregase activity cause severe congenital neutropenia (SCN) and 3-methylglutaconic aciduria type 7 (MGCA7). How Skd3 disagg...

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Detalles Bibliográficos
Autores principales:	Cupo, Ryan R., Rizo, Alexandrea N., Braun, Gabriel A., Tse, Eric, Chuang, Edward, Gupta, Kushol, Southworth, Daniel R., Shorter, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584538/ https://www.ncbi.nlm.nih.gov/pubmed/36170828 http://dx.doi.org/10.1016/j.celrep.2022.111408

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