Highly efficient generation of isogenic pluripotent stem cell models using prime editing

The recent development of prime editing (PE) genome engineering technologies has the potential to significantly simplify the generation of human pluripotent stem cell (hPSC)-based disease models. PE is a multicomponent editing system that uses a Cas9-nickase fused to a reverse transcriptase (nCas9-R...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Hanqin, Busquets, Oriol, Verma, Yogendra, Syed, Khaja Mohieddin, Kutnowski, Nitzan, Pangilinan, Gabriella R, Gilbert, Luke A, Bateup, Helen S, Rio, Donald C, Hockemeyer, Dirk, Soldner, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584603/
https://www.ncbi.nlm.nih.gov/pubmed/36069759
http://dx.doi.org/10.7554/eLife.79208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584603/
https://www.ncbi.nlm.nih.gov/pubmed/36069759
http://dx.doi.org/10.7554/eLife.79208

Ejemplares similares