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Molecular Mechanisms of Antifungal Resistance in Mucormycosis
Mucormycosis is one among the life-threatening fungal infections with high morbidity and mortality. It is an uncommon and rare infection targeting people with altered immunity. This lethal infection induced by fungi belonging to the Mucorales family is very progressive in nature. The incidence has i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584669/ https://www.ncbi.nlm.nih.gov/pubmed/36277891 http://dx.doi.org/10.1155/2022/6722245 |
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author | Ganesan, Priya Ganapathy, Dhanraj Sekaran, Saravanan Murthykumar, Karthikeyan Sundramoorthy, Ashok K. Pitchiah, Sivaperumal Shanmugam, Rajeshkumar |
author_facet | Ganesan, Priya Ganapathy, Dhanraj Sekaran, Saravanan Murthykumar, Karthikeyan Sundramoorthy, Ashok K. Pitchiah, Sivaperumal Shanmugam, Rajeshkumar |
author_sort | Ganesan, Priya |
collection | PubMed |
description | Mucormycosis is one among the life-threatening fungal infections with high morbidity and mortality. It is an uncommon and rare infection targeting people with altered immunity. This lethal infection induced by fungi belonging to the Mucorales family is very progressive in nature. The incidence has increased in recent decades owing to the rise in immunocompromised patients. Disease management involves a multimodal strategy including early administration of drugs and surgical removal of infected tissues. Among the antifungals, azoles and amphotericin B remain the gold standard drugs of choice for initial treatment. The order Mucorales are developing a high level of resistance to the available systemic antifungal drugs, and the efficacy still remains below par. Deciphering the molecular mechanisms behind the antifungal resistance in Mucormycosis would add vital information to our available antifungal armamentarium and design novel therapies. Therefore, in this review, we have discussed the mechanisms behind Mucormycosis antifungal resistance. Moreover, this review also highlights the basic mechanisms of action of antifungal drugs and the resistance landscape which is expected to augment future treatment strategies. |
format | Online Article Text |
id | pubmed-9584669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-95846692022-10-21 Molecular Mechanisms of Antifungal Resistance in Mucormycosis Ganesan, Priya Ganapathy, Dhanraj Sekaran, Saravanan Murthykumar, Karthikeyan Sundramoorthy, Ashok K. Pitchiah, Sivaperumal Shanmugam, Rajeshkumar Biomed Res Int Review Article Mucormycosis is one among the life-threatening fungal infections with high morbidity and mortality. It is an uncommon and rare infection targeting people with altered immunity. This lethal infection induced by fungi belonging to the Mucorales family is very progressive in nature. The incidence has increased in recent decades owing to the rise in immunocompromised patients. Disease management involves a multimodal strategy including early administration of drugs and surgical removal of infected tissues. Among the antifungals, azoles and amphotericin B remain the gold standard drugs of choice for initial treatment. The order Mucorales are developing a high level of resistance to the available systemic antifungal drugs, and the efficacy still remains below par. Deciphering the molecular mechanisms behind the antifungal resistance in Mucormycosis would add vital information to our available antifungal armamentarium and design novel therapies. Therefore, in this review, we have discussed the mechanisms behind Mucormycosis antifungal resistance. Moreover, this review also highlights the basic mechanisms of action of antifungal drugs and the resistance landscape which is expected to augment future treatment strategies. Hindawi 2022-10-13 /pmc/articles/PMC9584669/ /pubmed/36277891 http://dx.doi.org/10.1155/2022/6722245 Text en Copyright © 2022 Priya Ganesan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ganesan, Priya Ganapathy, Dhanraj Sekaran, Saravanan Murthykumar, Karthikeyan Sundramoorthy, Ashok K. Pitchiah, Sivaperumal Shanmugam, Rajeshkumar Molecular Mechanisms of Antifungal Resistance in Mucormycosis |
title | Molecular Mechanisms of Antifungal Resistance in Mucormycosis |
title_full | Molecular Mechanisms of Antifungal Resistance in Mucormycosis |
title_fullStr | Molecular Mechanisms of Antifungal Resistance in Mucormycosis |
title_full_unstemmed | Molecular Mechanisms of Antifungal Resistance in Mucormycosis |
title_short | Molecular Mechanisms of Antifungal Resistance in Mucormycosis |
title_sort | molecular mechanisms of antifungal resistance in mucormycosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584669/ https://www.ncbi.nlm.nih.gov/pubmed/36277891 http://dx.doi.org/10.1155/2022/6722245 |
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