Cargando…

Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model

In order to investigate the effects of clopidogrel rehabilitation on the levels of cardiac protein kinase C (PKC), cardiac heat shock protein 70 (HSP70), and cardiac index (CI) in rats with myocardial ischemia-reperfusion injury (MIRI), sixty Wistar rats are randomly divided into three groups (sham...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Qiaoyan, Wang, Lizhong, Ma, Hongyan, Cao, Qian, Ma, Jiagui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584675/
https://www.ncbi.nlm.nih.gov/pubmed/36277878
http://dx.doi.org/10.1155/2022/5823276
_version_ 1784813322322837504
author Ma, Qiaoyan
Wang, Lizhong
Ma, Hongyan
Cao, Qian
Ma, Jiagui
author_facet Ma, Qiaoyan
Wang, Lizhong
Ma, Hongyan
Cao, Qian
Ma, Jiagui
author_sort Ma, Qiaoyan
collection PubMed
description In order to investigate the effects of clopidogrel rehabilitation on the levels of cardiac protein kinase C (PKC), cardiac heat shock protein 70 (HSP70), and cardiac index (CI) in rats with myocardial ischemia-reperfusion injury (MIRI), sixty Wistar rats are randomly divided into three groups (sham operation group, model group, and clopidogrel group), with 20 rats in each group. The clopidogrel group is given clopidogrel by gavage, and the sham operation group and the model group are given the same amount of normal saline by gavage. The experimental results show that compared with the model group, the clopidogrel group has clear horizontal lines and cell edema. The myocardial infarction rate, creatine kinase-MB (CK-MB), and malondialdehyde (MDA) of the model group and clopidogrel group in the control sham operation group significantly increase.
format Online
Article
Text
id pubmed-9584675
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-95846752022-10-21 Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model Ma, Qiaoyan Wang, Lizhong Ma, Hongyan Cao, Qian Ma, Jiagui Biomed Res Int Research Article In order to investigate the effects of clopidogrel rehabilitation on the levels of cardiac protein kinase C (PKC), cardiac heat shock protein 70 (HSP70), and cardiac index (CI) in rats with myocardial ischemia-reperfusion injury (MIRI), sixty Wistar rats are randomly divided into three groups (sham operation group, model group, and clopidogrel group), with 20 rats in each group. The clopidogrel group is given clopidogrel by gavage, and the sham operation group and the model group are given the same amount of normal saline by gavage. The experimental results show that compared with the model group, the clopidogrel group has clear horizontal lines and cell edema. The myocardial infarction rate, creatine kinase-MB (CK-MB), and malondialdehyde (MDA) of the model group and clopidogrel group in the control sham operation group significantly increase. Hindawi 2022-10-13 /pmc/articles/PMC9584675/ /pubmed/36277878 http://dx.doi.org/10.1155/2022/5823276 Text en Copyright © 2022 Qiaoyan Ma et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ma, Qiaoyan
Wang, Lizhong
Ma, Hongyan
Cao, Qian
Ma, Jiagui
Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model
title Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model
title_full Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model
title_fullStr Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model
title_full_unstemmed Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model
title_short Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model
title_sort effects of clopidogrel rehabilitation on cardiac protein kinase c, cardiac heat shock protein 70, and ci in miri rat model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584675/
https://www.ncbi.nlm.nih.gov/pubmed/36277878
http://dx.doi.org/10.1155/2022/5823276
work_keys_str_mv AT maqiaoyan effectsofclopidogrelrehabilitationoncardiacproteinkinaseccardiacheatshockprotein70andciinmiriratmodel
AT wanglizhong effectsofclopidogrelrehabilitationoncardiacproteinkinaseccardiacheatshockprotein70andciinmiriratmodel
AT mahongyan effectsofclopidogrelrehabilitationoncardiacproteinkinaseccardiacheatshockprotein70andciinmiriratmodel
AT caoqian effectsofclopidogrelrehabilitationoncardiacproteinkinaseccardiacheatshockprotein70andciinmiriratmodel
AT majiagui effectsofclopidogrelrehabilitationoncardiacproteinkinaseccardiacheatshockprotein70andciinmiriratmodel