Cargando…

A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome

OBJECTIVE: This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). METHODS: 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shengyuan, Niu, Shanshan, Wen, Siwan, Zhang, Mengru, Shi, Cuiqin, Qiu, Zhongmin, Yu, Li, Xu, Xianghuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584720/
https://www.ncbi.nlm.nih.gov/pubmed/36276929
http://dx.doi.org/10.1155/2022/2726261
_version_ 1784813333768044544
author Wang, Shengyuan
Niu, Shanshan
Wen, Siwan
Zhang, Mengru
Shi, Cuiqin
Qiu, Zhongmin
Yu, Li
Xu, Xianghuai
author_facet Wang, Shengyuan
Niu, Shanshan
Wen, Siwan
Zhang, Mengru
Shi, Cuiqin
Qiu, Zhongmin
Yu, Li
Xu, Xianghuai
author_sort Wang, Shengyuan
collection PubMed
description OBJECTIVE: This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). METHODS: 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis without cough, and 39 healthy controls (HCs) were enrolled between January 2013 and December 2018. All participants underwent a capsaicin cough-sensitivity test and cytology of induced sputum. The concentration of calcitonin-gene-related peptide (CGPR), histamine, prostaglandin (PG) E2, and eosinophil cationic protein (ECP) in induced sputum were measured using enzyme-linked immunosorbent assays (ELISAs). RESULTS: The lowest concentration of capsaicin solution that induced ≥5 coughs (C5) was decreased markedly in patients with UACS induced by rhinitis compared with SBS patients (1.95 ± 2.92 vs. 31.2 ± 58.6 mol/L, P < 0.001), indicating higher cough-reflex sensitivity among UACS patients induced by rhinitis. However, there was no difference of these threshold between SBS patients and patients with sinusitis without cough and HCs. The percentage of neutrophils in sputum was increased remarkably in patients with SBS compared with HCs (40.0 ± 48.5% vs. 5.5 ± 9.0%, P < 0.001). A higher concentration of CGPR, histamine, and PGE2 was observed in induced sputum from patients with UACS induced by rhinitis than that in controls, and the ECP level was increased significantly in UACS induced by rhinitis compared with that in the other three groups. CONCLUSIONS: Cough-reflex sensitivity and airway inflammation in patients with SBS were different in patients with UACS induced by rhinitis. Thus, the mechanism of cough in those two patient populations might differ. Our study is registered in the Chinese Clinical Trials Register (https://www.chictr.org.cn/) as ChiCTR-TRC-00000152.
format Online
Article
Text
id pubmed-9584720
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-95847202022-10-21 A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome Wang, Shengyuan Niu, Shanshan Wen, Siwan Zhang, Mengru Shi, Cuiqin Qiu, Zhongmin Yu, Li Xu, Xianghuai Can Respir J Research Article OBJECTIVE: This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). METHODS: 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis without cough, and 39 healthy controls (HCs) were enrolled between January 2013 and December 2018. All participants underwent a capsaicin cough-sensitivity test and cytology of induced sputum. The concentration of calcitonin-gene-related peptide (CGPR), histamine, prostaglandin (PG) E2, and eosinophil cationic protein (ECP) in induced sputum were measured using enzyme-linked immunosorbent assays (ELISAs). RESULTS: The lowest concentration of capsaicin solution that induced ≥5 coughs (C5) was decreased markedly in patients with UACS induced by rhinitis compared with SBS patients (1.95 ± 2.92 vs. 31.2 ± 58.6 mol/L, P < 0.001), indicating higher cough-reflex sensitivity among UACS patients induced by rhinitis. However, there was no difference of these threshold between SBS patients and patients with sinusitis without cough and HCs. The percentage of neutrophils in sputum was increased remarkably in patients with SBS compared with HCs (40.0 ± 48.5% vs. 5.5 ± 9.0%, P < 0.001). A higher concentration of CGPR, histamine, and PGE2 was observed in induced sputum from patients with UACS induced by rhinitis than that in controls, and the ECP level was increased significantly in UACS induced by rhinitis compared with that in the other three groups. CONCLUSIONS: Cough-reflex sensitivity and airway inflammation in patients with SBS were different in patients with UACS induced by rhinitis. Thus, the mechanism of cough in those two patient populations might differ. Our study is registered in the Chinese Clinical Trials Register (https://www.chictr.org.cn/) as ChiCTR-TRC-00000152. Hindawi 2022-10-13 /pmc/articles/PMC9584720/ /pubmed/36276929 http://dx.doi.org/10.1155/2022/2726261 Text en Copyright © 2022 Shengyuan Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Shengyuan
Niu, Shanshan
Wen, Siwan
Zhang, Mengru
Shi, Cuiqin
Qiu, Zhongmin
Yu, Li
Xu, Xianghuai
A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
title A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
title_full A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
title_fullStr A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
title_full_unstemmed A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
title_short A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
title_sort study on cough sensitivity and airway inflammation in patients with sinobronchial syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584720/
https://www.ncbi.nlm.nih.gov/pubmed/36276929
http://dx.doi.org/10.1155/2022/2726261
work_keys_str_mv AT wangshengyuan astudyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT niushanshan astudyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT wensiwan astudyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT zhangmengru astudyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT shicuiqin astudyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT qiuzhongmin astudyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT yuli astudyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT xuxianghuai astudyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT wangshengyuan studyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT niushanshan studyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT wensiwan studyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT zhangmengru studyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT shicuiqin studyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT qiuzhongmin studyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT yuli studyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome
AT xuxianghuai studyoncoughsensitivityandairwayinflammationinpatientswithsinobronchialsyndrome