The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK....

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Detalles Bibliográficos
Autores principales: Zhang, Chen-Song, Li, Mengqi, Wang, Yu, Li, Xiaoyang, Zong, Yue, Long, Shating, Zhang, Mingliang, Feng, Jin-Wei, Wei, Xiaoyan, Liu, Yan-Hui, Zhang, Baoding, Wu, Jianfeng, Zhang, Cixiong, Lian, Wenhua, Ma, Teng, Tian, Xiao, Qu, Qi, Yu, Yaxin, Xiong, Jinye, Liu, Dong-Tai, Wu, Zhenhua, Zhu, Mingxia, Xie, Changchuan, Wu, Yaying, Xu, Zheni, Yang, Chunyan, Chen, Junjie, Huang, Guohong, He, Qingxia, Huang, Xi, Zhang, Lei, Sun, Xiufeng, Liu, Qingfeng, Ghafoor, Abdul, Gui, Fu, Zheng, Kaili, Wang, Wen, Wang, Zhi-Chao, Yu, Yong, Zhao, Qingliang, Lin, Shu-Yong, Wang, Zhi-Xin, Piao, Hai-Long, Deng, Xianming, Lin, Sheng-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584815/
https://www.ncbi.nlm.nih.gov/pubmed/36217034
http://dx.doi.org/10.1038/s42255-022-00640-7

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