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Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history
The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we collected 201 serum samples from persons with a single infection or multiple vaccine exposures, or both. We measured their neutralization titers against 15 natural variants and 7 variants with engineered spike mut...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584854/ https://www.ncbi.nlm.nih.gov/pubmed/36356586 http://dx.doi.org/10.1016/j.chom.2022.10.012 |
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| author | Wang, Wei Lusvarghi, Sabrina Subramanian, Rahul Epsi, Nusrat J. Wang, Richard Goguet, Emilie Fries, Anthony C. Echegaray, Fernando Vassell, Russell Coggins, Si’Ana A. Richard, Stephanie A. Lindholm, David A. Mende, Katrin Ewers, Evan C. Larson, Derek T. Colombo, Rhonda E. Colombo, Christopher J. Joseph, Janet O. Rozman, Julia S. Smith, Alfred Lalani, Tahaniyat Berjohn, Catherine M. Maves, Ryan C. Jones, Milissa U. Mody, Rupal Huprikar, Nikhil Livezey, Jeffrey Saunders, David Hollis-Perry, Monique Wang, Gregory Ganesan, Anuradha Simons, Mark P. Broder, Christopher C. Tribble, David R. Laing, Eric D. Agan, Brian K. Burgess, Timothy H. Mitre, Edward Pollett, Simon D. Katzelnick, Leah C. Weiss, Carol D. |
| author_facet | Wang, Wei Lusvarghi, Sabrina Subramanian, Rahul Epsi, Nusrat J. Wang, Richard Goguet, Emilie Fries, Anthony C. Echegaray, Fernando Vassell, Russell Coggins, Si’Ana A. Richard, Stephanie A. Lindholm, David A. Mende, Katrin Ewers, Evan C. Larson, Derek T. Colombo, Rhonda E. Colombo, Christopher J. Joseph, Janet O. Rozman, Julia S. Smith, Alfred Lalani, Tahaniyat Berjohn, Catherine M. Maves, Ryan C. Jones, Milissa U. Mody, Rupal Huprikar, Nikhil Livezey, Jeffrey Saunders, David Hollis-Perry, Monique Wang, Gregory Ganesan, Anuradha Simons, Mark P. Broder, Christopher C. Tribble, David R. Laing, Eric D. Agan, Brian K. Burgess, Timothy H. Mitre, Edward Pollett, Simon D. Katzelnick, Leah C. Weiss, Carol D. |
| author_sort | Wang, Wei |
| collection | PubMed |
| description | The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we collected 201 serum samples from persons with a single infection or multiple vaccine exposures, or both. We measured their neutralization titers against 15 natural variants and 7 variants with engineered spike mutations and analyzed antigenic diversity. Antigenic maps of primary infection sera showed that Omicron sublineages BA.2, BA.4/BA.5, and BA.2.12.1 are distinct from BA.1 and more similar to Beta/Gamma/Mu variants. Three mRNA COVID-19 vaccinations increased neutralization of BA.1 more than BA.4/BA.5 or BA.2.12.1. BA.1 post-vaccination infection elicited higher neutralization titers to all variants than three vaccinations alone, although with less neutralization to BA.2.12.1 and BA.4/BA.5. Those with BA.1 infection after two or three vaccinations had similar neutralization titer magnitude and antigenic recognition. Accounting for antigenic differences among variants when interpreting neutralization titers can aid the understanding of complex patterns in humoral immunity that informs the selection of future COVID-19 vaccine strains. |
| format | Online Article Text |
| id | pubmed-9584854 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Cell Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-95848542022-10-21 Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history Wang, Wei Lusvarghi, Sabrina Subramanian, Rahul Epsi, Nusrat J. Wang, Richard Goguet, Emilie Fries, Anthony C. Echegaray, Fernando Vassell, Russell Coggins, Si’Ana A. Richard, Stephanie A. Lindholm, David A. Mende, Katrin Ewers, Evan C. Larson, Derek T. Colombo, Rhonda E. Colombo, Christopher J. Joseph, Janet O. Rozman, Julia S. Smith, Alfred Lalani, Tahaniyat Berjohn, Catherine M. Maves, Ryan C. Jones, Milissa U. Mody, Rupal Huprikar, Nikhil Livezey, Jeffrey Saunders, David Hollis-Perry, Monique Wang, Gregory Ganesan, Anuradha Simons, Mark P. Broder, Christopher C. Tribble, David R. Laing, Eric D. Agan, Brian K. Burgess, Timothy H. Mitre, Edward Pollett, Simon D. Katzelnick, Leah C. Weiss, Carol D. Cell Host Microbe Article The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we collected 201 serum samples from persons with a single infection or multiple vaccine exposures, or both. We measured their neutralization titers against 15 natural variants and 7 variants with engineered spike mutations and analyzed antigenic diversity. Antigenic maps of primary infection sera showed that Omicron sublineages BA.2, BA.4/BA.5, and BA.2.12.1 are distinct from BA.1 and more similar to Beta/Gamma/Mu variants. Three mRNA COVID-19 vaccinations increased neutralization of BA.1 more than BA.4/BA.5 or BA.2.12.1. BA.1 post-vaccination infection elicited higher neutralization titers to all variants than three vaccinations alone, although with less neutralization to BA.2.12.1 and BA.4/BA.5. Those with BA.1 infection after two or three vaccinations had similar neutralization titer magnitude and antigenic recognition. Accounting for antigenic differences among variants when interpreting neutralization titers can aid the understanding of complex patterns in humoral immunity that informs the selection of future COVID-19 vaccine strains. Cell Press 2022-12-14 2022-10-21 /pmc/articles/PMC9584854/ /pubmed/36356586 http://dx.doi.org/10.1016/j.chom.2022.10.012 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Wang, Wei Lusvarghi, Sabrina Subramanian, Rahul Epsi, Nusrat J. Wang, Richard Goguet, Emilie Fries, Anthony C. Echegaray, Fernando Vassell, Russell Coggins, Si’Ana A. Richard, Stephanie A. Lindholm, David A. Mende, Katrin Ewers, Evan C. Larson, Derek T. Colombo, Rhonda E. Colombo, Christopher J. Joseph, Janet O. Rozman, Julia S. Smith, Alfred Lalani, Tahaniyat Berjohn, Catherine M. Maves, Ryan C. Jones, Milissa U. Mody, Rupal Huprikar, Nikhil Livezey, Jeffrey Saunders, David Hollis-Perry, Monique Wang, Gregory Ganesan, Anuradha Simons, Mark P. Broder, Christopher C. Tribble, David R. Laing, Eric D. Agan, Brian K. Burgess, Timothy H. Mitre, Edward Pollett, Simon D. Katzelnick, Leah C. Weiss, Carol D. Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history |
| title | Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history |
| title_full | Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history |
| title_fullStr | Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history |
| title_full_unstemmed | Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history |
| title_short | Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history |
| title_sort | antigenic cartography of well-characterized human sera shows sars-cov-2 neutralization differences based on infection and vaccination history |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584854/ https://www.ncbi.nlm.nih.gov/pubmed/36356586 http://dx.doi.org/10.1016/j.chom.2022.10.012 |
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