Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression

The systemic metabolic shifts that occur during aging and the local metabolic alterations of a tumor, its stroma and their communication cooperate to establish a unique tumor microenvironment (TME) fostering cancer progression. Here, we show that methylmalonic acid (MMA), an aging-increased oncometa...

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Detalles Bibliográficos
Autores principales: Li, Zhongchi, Low, Vivien, Luga, Valbona, Sun, Janet, Earlie, Ethan, Parang, Bobak, Shobana Ganesh, Kripa, Cho, Sungyun, Endress, Jennifer, Schild, Tanya, Hu, Mengying, Lyden, David, Jin, Wenbing, Guo, Chunjun, Dephoure, Noah, Cantley, Lewis C., Laughney, Ashley M., Blenis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584945/
https://www.ncbi.nlm.nih.gov/pubmed/36266345
http://dx.doi.org/10.1038/s41467-022-33862-0

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