p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and contribute to cancer development is unclear. Here we show that inducing the p5...

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Detalles Bibliográficos
Autores principales: Murai, Kasumi, Dentro, Stefan, Ong, Swee Hoe, Sood, Roshan, Fernandez-Antoran, David, Herms, Albert, Kostiou, Vasiliki, Abnizova, Irina, Hall, Benjamin A., Gerstung, Moritz, Jones, Philip H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584949/
https://www.ncbi.nlm.nih.gov/pubmed/36266286
http://dx.doi.org/10.1038/s41467-022-33945-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584949/
https://www.ncbi.nlm.nih.gov/pubmed/36266286
http://dx.doi.org/10.1038/s41467-022-33945-y

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