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p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and contribute to cancer development is unclear. Here we show that inducing the p5...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584949/ https://www.ncbi.nlm.nih.gov/pubmed/36266286 http://dx.doi.org/10.1038/s41467-022-33945-y |