Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment

With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quantitative hazard characterisation becomes more important. Physiologically based kinetic (PBK...

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Detalles Bibliográficos
Autores principales: Najjar, Abdulkarim, Punt, Ans, Wambaugh, John, Paini, Alicia, Ellison, Corie, Fragki, Styliani, Bianchi, Enrica, Zhang, Fagen, Westerhout, Joost, Mueller, Dennis, Li, Hequn, Shi, Quan, Gant, Timothy W., Botham, Phil, Bars, Rémi, Piersma, Aldert, van Ravenzwaay, Ben, Kramer, Nynke I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Meeting Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584981/
https://www.ncbi.nlm.nih.gov/pubmed/36063173
http://dx.doi.org/10.1007/s00204-022-03356-5

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