A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation

Hepatic encephalopathy (HE) is a common complication of chronic liver disease, characterized by an altered mental state and hyperammonemia. Insight into the brain pathophysiology of HE is limited due to a paucity of well-characterized HE models beyond the rat bile duct ligation (BDL) model. Here, we...

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Detalles Bibliográficos
Autores principales: Claeys, Wouter, Van Hoecke, Lien, Geerts, Anja, Van Vlierberghe, Hans, Lefere, Sander, Van Imschoot, Griet, Van Wonterghem, Elien, Ghesquière, Bart, Vandenbroucke, Roosmarijn E., Van Steenkiste, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585018/
https://www.ncbi.nlm.nih.gov/pubmed/36266427
http://dx.doi.org/10.1038/s41598-022-22423-6

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