A BDNF-TrkB autocrine loop enhances senescent cell viability

Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP) whereby cells secrete pro-inflammatory and tissue-remodeling factors. Given that the SASP exacerbates age-associated pathologies, some aging interventions aim at...

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Detalles Bibliográficos
Autores principales: Anerillas, Carlos, Herman, Allison B., Munk, Rachel, Garrido, Amanda, Lam, Kwan-Wood Gabriel, Payea, Matthew J., Rossi, Martina, Tsitsipatis, Dimitrios, Martindale, Jennifer L., Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Cui, Chang-Yi, De, Supriyo, Abdelmohsen, Kotb, de Cabo, Rafael, Gorospe, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585019/
https://www.ncbi.nlm.nih.gov/pubmed/36266274
http://dx.doi.org/10.1038/s41467-022-33709-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585019/
https://www.ncbi.nlm.nih.gov/pubmed/36266274
http://dx.doi.org/10.1038/s41467-022-33709-8

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