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Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma
Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy against glioblastoma (GBM), however, TAMs are heterogeneous, and there are no clear markers to distinguish immunosuppressive and potentially immune-activating populations. Here we identify a subset of CD169(+) macropha...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585054/ https://www.ncbi.nlm.nih.gov/pubmed/36266311 http://dx.doi.org/10.1038/s41467-022-34001-5 |
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author | Kim, Hyun-Jin Park, Jang Hyun Kim, Hyeon Cheol Kim, Chae Won Kang, In Lee, Heung Kyu |
author_facet | Kim, Hyun-Jin Park, Jang Hyun Kim, Hyeon Cheol Kim, Chae Won Kang, In Lee, Heung Kyu |
author_sort | Kim, Hyun-Jin |
collection | PubMed |
description | Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy against glioblastoma (GBM), however, TAMs are heterogeneous, and there are no clear markers to distinguish immunosuppressive and potentially immune-activating populations. Here we identify a subset of CD169(+) macrophages promoting an anti-tumoral microenvironment in GBM. Using single-cell transcriptome analysis, we find that CD169(+) macrophages in human and mouse gliomas produce pro-inflammatory chemokines, leading to the accumulation of T cells and NK cells. CD169 expression on macrophages facilitates phagocytosis of apoptotic glioma cells and hence tumor-specific T cell responses. Depletion of CD169(+) macrophages leads to functionally impaired antitumor lymphocytes and poorer survival of glioma-bearing mice. We show that NK-cell-derived IFN-γ is critical for the accumulation of blood monocyte-derived CD169(+) macrophages in gliomas. Our work thus identifies a well-distinguished TAM subset promoting antitumor immunity against GBM, and identifies key factors that might shift the balance from immunosuppressive to anti-tumor TAM. |
format | Online Article Text |
id | pubmed-9585054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95850542022-10-22 Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma Kim, Hyun-Jin Park, Jang Hyun Kim, Hyeon Cheol Kim, Chae Won Kang, In Lee, Heung Kyu Nat Commun Article Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy against glioblastoma (GBM), however, TAMs are heterogeneous, and there are no clear markers to distinguish immunosuppressive and potentially immune-activating populations. Here we identify a subset of CD169(+) macrophages promoting an anti-tumoral microenvironment in GBM. Using single-cell transcriptome analysis, we find that CD169(+) macrophages in human and mouse gliomas produce pro-inflammatory chemokines, leading to the accumulation of T cells and NK cells. CD169 expression on macrophages facilitates phagocytosis of apoptotic glioma cells and hence tumor-specific T cell responses. Depletion of CD169(+) macrophages leads to functionally impaired antitumor lymphocytes and poorer survival of glioma-bearing mice. We show that NK-cell-derived IFN-γ is critical for the accumulation of blood monocyte-derived CD169(+) macrophages in gliomas. Our work thus identifies a well-distinguished TAM subset promoting antitumor immunity against GBM, and identifies key factors that might shift the balance from immunosuppressive to anti-tumor TAM. Nature Publishing Group UK 2022-10-20 /pmc/articles/PMC9585054/ /pubmed/36266311 http://dx.doi.org/10.1038/s41467-022-34001-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kim, Hyun-Jin Park, Jang Hyun Kim, Hyeon Cheol Kim, Chae Won Kang, In Lee, Heung Kyu Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma |
title | Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma |
title_full | Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma |
title_fullStr | Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma |
title_full_unstemmed | Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma |
title_short | Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma |
title_sort | blood monocyte-derived cd169(+) macrophages contribute to antitumor immunity against glioblastoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585054/ https://www.ncbi.nlm.nih.gov/pubmed/36266311 http://dx.doi.org/10.1038/s41467-022-34001-5 |
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