Cargando…
An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air”
Acute pulmonary edema is a serious condition that may occur as a result of increased hydrostatic forces within the lung microvasculature or increased microvascular permeability. Heart failure or other cardiac or renal disease are common causes of cardiogenic pulmonary edema. However, pulmonary edema...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585243/ https://www.ncbi.nlm.nih.gov/pubmed/36277204 http://dx.doi.org/10.3389/fphys.2022.1007316 |
_version_ | 1784813448726577152 |
---|---|
author | Tetzlaff, Kay Swenson, Erik R. Bärtsch, Peter |
author_facet | Tetzlaff, Kay Swenson, Erik R. Bärtsch, Peter |
author_sort | Tetzlaff, Kay |
collection | PubMed |
description | Acute pulmonary edema is a serious condition that may occur as a result of increased hydrostatic forces within the lung microvasculature or increased microvascular permeability. Heart failure or other cardiac or renal disease are common causes of cardiogenic pulmonary edema. However, pulmonary edema may even occur in young and healthy individuals when exposed to extreme environments, such as immersion in water or at high altitude. Immersion pulmonary edema (IPE) and high-altitude pulmonary edema (HAPE) share some morphological and clinical characteristics; however, their underlying mechanisms may be different. An emerging understanding of IPE indicates that an increase in pulmonary artery and capillary pressures caused by substantial redistribution of venous blood from the extremities to the chest, in combination with stimuli aggravating the effects of water immersion, such as exercise and cold temperature, play an important role, distinct from hypoxia-induced vasoconstriction in high altitude pulmonary edema. This review aims at a current perspective on both IPE and HAPE, providing a comparative view of clinical presentation and pathophysiology. A particular emphasis will be on recent advances in understanding of the pathophysiology and occurrence of IPE with a future perspective on remaining research needs. |
format | Online Article Text |
id | pubmed-9585243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95852432022-10-22 An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” Tetzlaff, Kay Swenson, Erik R. Bärtsch, Peter Front Physiol Physiology Acute pulmonary edema is a serious condition that may occur as a result of increased hydrostatic forces within the lung microvasculature or increased microvascular permeability. Heart failure or other cardiac or renal disease are common causes of cardiogenic pulmonary edema. However, pulmonary edema may even occur in young and healthy individuals when exposed to extreme environments, such as immersion in water or at high altitude. Immersion pulmonary edema (IPE) and high-altitude pulmonary edema (HAPE) share some morphological and clinical characteristics; however, their underlying mechanisms may be different. An emerging understanding of IPE indicates that an increase in pulmonary artery and capillary pressures caused by substantial redistribution of venous blood from the extremities to the chest, in combination with stimuli aggravating the effects of water immersion, such as exercise and cold temperature, play an important role, distinct from hypoxia-induced vasoconstriction in high altitude pulmonary edema. This review aims at a current perspective on both IPE and HAPE, providing a comparative view of clinical presentation and pathophysiology. A particular emphasis will be on recent advances in understanding of the pathophysiology and occurrence of IPE with a future perspective on remaining research needs. Frontiers Media S.A. 2022-10-07 /pmc/articles/PMC9585243/ /pubmed/36277204 http://dx.doi.org/10.3389/fphys.2022.1007316 Text en Copyright © 2022 Tetzlaff, Swenson and Bärtsch. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Tetzlaff, Kay Swenson, Erik R. Bärtsch, Peter An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” |
title | An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” |
title_full | An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” |
title_fullStr | An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” |
title_full_unstemmed | An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” |
title_short | An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” |
title_sort | update on environment-induced pulmonary edema – “when the lungs leak under water and in thin air” |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585243/ https://www.ncbi.nlm.nih.gov/pubmed/36277204 http://dx.doi.org/10.3389/fphys.2022.1007316 |
work_keys_str_mv | AT tetzlaffkay anupdateonenvironmentinducedpulmonaryedemawhenthelungsleakunderwaterandinthinair AT swensonerikr anupdateonenvironmentinducedpulmonaryedemawhenthelungsleakunderwaterandinthinair AT bartschpeter anupdateonenvironmentinducedpulmonaryedemawhenthelungsleakunderwaterandinthinair AT tetzlaffkay updateonenvironmentinducedpulmonaryedemawhenthelungsleakunderwaterandinthinair AT swensonerikr updateonenvironmentinducedpulmonaryedemawhenthelungsleakunderwaterandinthinair AT bartschpeter updateonenvironmentinducedpulmonaryedemawhenthelungsleakunderwaterandinthinair |