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Polymeric nanoparticles—Promising carriers for cancer therapy

Polymeric nanoparticles (NPs) play an important role in controlled cancer drug delivery. Anticancer drugs can be conjugated or encapsulated by polymeric nanocarriers, which are known as polymeric nanomedicine. Polymeric nanomedicine has shown its potential in providing sustained release of drugs wit...

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Autores principales: Xiao, Xiao, Teng, Fei, Shi, Changkuo, Chen, Junyu, Wu, Shuqing, Wang, Bao, Meng, Xiang, Essiet Imeh, Aniekan, Li, Wenliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585261/
https://www.ncbi.nlm.nih.gov/pubmed/36277396
http://dx.doi.org/10.3389/fbioe.2022.1024143
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author Xiao, Xiao
Teng, Fei
Shi, Changkuo
Chen, Junyu
Wu, Shuqing
Wang, Bao
Meng, Xiang
Essiet Imeh, Aniekan
Li, Wenliang
author_facet Xiao, Xiao
Teng, Fei
Shi, Changkuo
Chen, Junyu
Wu, Shuqing
Wang, Bao
Meng, Xiang
Essiet Imeh, Aniekan
Li, Wenliang
author_sort Xiao, Xiao
collection PubMed
description Polymeric nanoparticles (NPs) play an important role in controlled cancer drug delivery. Anticancer drugs can be conjugated or encapsulated by polymeric nanocarriers, which are known as polymeric nanomedicine. Polymeric nanomedicine has shown its potential in providing sustained release of drugs with reduced cytotoxicity and modified tumor retention, but until now, few delivery systems loading drugs have been able to meet clinical demands, so more efforts are needed. This research reviews the current state of the cancer drug-loading system by exhibiting a series of published articles that highlight the novelty and functions from a variety of different architectures including micelles, liposomes, dendrimers, polymersomes, hydrogels, and metal–organic frameworks. These may contribute to the development of useful polymeric NPs to achieve different therapeutic purposes.
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spelling pubmed-95852612022-10-22 Polymeric nanoparticles—Promising carriers for cancer therapy Xiao, Xiao Teng, Fei Shi, Changkuo Chen, Junyu Wu, Shuqing Wang, Bao Meng, Xiang Essiet Imeh, Aniekan Li, Wenliang Front Bioeng Biotechnol Bioengineering and Biotechnology Polymeric nanoparticles (NPs) play an important role in controlled cancer drug delivery. Anticancer drugs can be conjugated or encapsulated by polymeric nanocarriers, which are known as polymeric nanomedicine. Polymeric nanomedicine has shown its potential in providing sustained release of drugs with reduced cytotoxicity and modified tumor retention, but until now, few delivery systems loading drugs have been able to meet clinical demands, so more efforts are needed. This research reviews the current state of the cancer drug-loading system by exhibiting a series of published articles that highlight the novelty and functions from a variety of different architectures including micelles, liposomes, dendrimers, polymersomes, hydrogels, and metal–organic frameworks. These may contribute to the development of useful polymeric NPs to achieve different therapeutic purposes. Frontiers Media S.A. 2022-10-07 /pmc/articles/PMC9585261/ /pubmed/36277396 http://dx.doi.org/10.3389/fbioe.2022.1024143 Text en Copyright © 2022 Xiao, Teng, Shi, Chen, Wu, Wang, Meng, Essiet Imeh and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Xiao, Xiao
Teng, Fei
Shi, Changkuo
Chen, Junyu
Wu, Shuqing
Wang, Bao
Meng, Xiang
Essiet Imeh, Aniekan
Li, Wenliang
Polymeric nanoparticles—Promising carriers for cancer therapy
title Polymeric nanoparticles—Promising carriers for cancer therapy
title_full Polymeric nanoparticles—Promising carriers for cancer therapy
title_fullStr Polymeric nanoparticles—Promising carriers for cancer therapy
title_full_unstemmed Polymeric nanoparticles—Promising carriers for cancer therapy
title_short Polymeric nanoparticles—Promising carriers for cancer therapy
title_sort polymeric nanoparticles—promising carriers for cancer therapy
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585261/
https://www.ncbi.nlm.nih.gov/pubmed/36277396
http://dx.doi.org/10.3389/fbioe.2022.1024143
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