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Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential

Bacteria are important symbionts for humans, which sustain substantial influences on our health. Interestingly, some bastrains have been identified to have therapeutic applications, notably for antitumor activity. Thereby, oncologists have developed various therapeutic models and investigated the po...

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Autores principales: Luo, Miao, Chen, Xiaoyu, Gao, Haojin, Yang, Fan, Chen, Jianxiang, Qiao, Yiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585267/
https://www.ncbi.nlm.nih.gov/pubmed/36276157
http://dx.doi.org/10.3389/fonc.2022.980111
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author Luo, Miao
Chen, Xiaoyu
Gao, Haojin
Yang, Fan
Chen, Jianxiang
Qiao, Yiting
author_facet Luo, Miao
Chen, Xiaoyu
Gao, Haojin
Yang, Fan
Chen, Jianxiang
Qiao, Yiting
author_sort Luo, Miao
collection PubMed
description Bacteria are important symbionts for humans, which sustain substantial influences on our health. Interestingly, some bastrains have been identified to have therapeutic applications, notably for antitumor activity. Thereby, oncologists have developed various therapeutic models and investigated the potential antitumor mechanisms for bacteria-mediated cancer therapy (BCT). Even though BCT has a long history and exhibits remarkable therapeutic efficacy in pre-clinical animal models, its clinical translation still lags and requires further breakthroughs. This review aims to focus on the established strains of therapeutic bacteria and their antitumor mechanisms, including the stimulation of host immune responses, direct cytotoxicity, the interference on cellular signal transduction, extracellular matrix remodeling, neoangiogenesis, and metabolism, as well as vehicles for drug delivery and gene therapy. Moreover, a brief discussion is proposed regarding the important future directions for this fantastic research field of BCT at the end of this review.
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spelling pubmed-95852672022-10-22 Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential Luo, Miao Chen, Xiaoyu Gao, Haojin Yang, Fan Chen, Jianxiang Qiao, Yiting Front Oncol Oncology Bacteria are important symbionts for humans, which sustain substantial influences on our health. Interestingly, some bastrains have been identified to have therapeutic applications, notably for antitumor activity. Thereby, oncologists have developed various therapeutic models and investigated the potential antitumor mechanisms for bacteria-mediated cancer therapy (BCT). Even though BCT has a long history and exhibits remarkable therapeutic efficacy in pre-clinical animal models, its clinical translation still lags and requires further breakthroughs. This review aims to focus on the established strains of therapeutic bacteria and their antitumor mechanisms, including the stimulation of host immune responses, direct cytotoxicity, the interference on cellular signal transduction, extracellular matrix remodeling, neoangiogenesis, and metabolism, as well as vehicles for drug delivery and gene therapy. Moreover, a brief discussion is proposed regarding the important future directions for this fantastic research field of BCT at the end of this review. Frontiers Media S.A. 2022-10-07 /pmc/articles/PMC9585267/ /pubmed/36276157 http://dx.doi.org/10.3389/fonc.2022.980111 Text en Copyright © 2022 Luo, Chen, Gao, Yang, Chen and Qiao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Luo, Miao
Chen, Xiaoyu
Gao, Haojin
Yang, Fan
Chen, Jianxiang
Qiao, Yiting
Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential
title Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential
title_full Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential
title_fullStr Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential
title_full_unstemmed Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential
title_short Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential
title_sort bacteria-mediated cancer therapy: a versatile bio-sapper with translational potential
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585267/
https://www.ncbi.nlm.nih.gov/pubmed/36276157
http://dx.doi.org/10.3389/fonc.2022.980111
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