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Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children
AIM: This is a case-controlled study, with two hundred children enrolled. They were divided into an obese group of 100 children who had BMI ≥ 95th percentile according to CDC criteria and a group of 100 children with normal weight. All enrolled children were subjected to detailed medical history and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585482/ https://www.ncbi.nlm.nih.gov/pubmed/36276297 http://dx.doi.org/10.2147/DMSO.S377072 |
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author | El Sehmawy, Asmaa A Diab, Fatma Elzhraa Ahmed Hassan, Donia Ahmed Mohammed, Doaa Sayed Gamal El Din Al Anany, Mona Eldesoky, Noha A Elamir, Reham Yousri |
author_facet | El Sehmawy, Asmaa A Diab, Fatma Elzhraa Ahmed Hassan, Donia Ahmed Mohammed, Doaa Sayed Gamal El Din Al Anany, Mona Eldesoky, Noha A Elamir, Reham Yousri |
author_sort | El Sehmawy, Asmaa A |
collection | PubMed |
description | AIM: This is a case-controlled study, with two hundred children enrolled. They were divided into an obese group of 100 children who had BMI ≥ 95th percentile according to CDC criteria and a group of 100 children with normal weight. All enrolled children were subjected to detailed medical history and clinical examination, in addition to measuring fasting blood sugar, fasting serum insulin, HOMA-IR calculation, lipid profile analysis, total serum cholesterol, low- and high-density lipoproteins (LDL and HDL), and serum triglyceride (TG). Two adipokines (lipocalin-2 and adipsin) serum levels plus IL-10 serum level were assessed. RESULTS: Higher Z score of weight, MI, and waist/height ratio and high serum cholesterol, LDL, TG, and low HDL were observed in obese children. Higher levels of serum lipocalin-2 and adipsin and lower IL-10 blood level were observed in the obese group in comparison with the normal weight children. Higher insulin resistance index was observed in the obese group, with positive correlation of HOMA-IR with the anthropometric measurements and lipocalin serum level, while negative correlation was observed between IL-10 and fasting insulin in obese children. CONCLUSION: Simple measurement of general and central adiposity markers and serum lipocalin-2 can predict insulin resistance in obese children while serum adipsin and IL-10 had no association with insulin resistance. |
format | Online Article Text |
id | pubmed-9585482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-95854822022-10-22 Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children El Sehmawy, Asmaa A Diab, Fatma Elzhraa Ahmed Hassan, Donia Ahmed Mohammed, Doaa Sayed Gamal El Din Al Anany, Mona Eldesoky, Noha A Elamir, Reham Yousri Diabetes Metab Syndr Obes Original Research AIM: This is a case-controlled study, with two hundred children enrolled. They were divided into an obese group of 100 children who had BMI ≥ 95th percentile according to CDC criteria and a group of 100 children with normal weight. All enrolled children were subjected to detailed medical history and clinical examination, in addition to measuring fasting blood sugar, fasting serum insulin, HOMA-IR calculation, lipid profile analysis, total serum cholesterol, low- and high-density lipoproteins (LDL and HDL), and serum triglyceride (TG). Two adipokines (lipocalin-2 and adipsin) serum levels plus IL-10 serum level were assessed. RESULTS: Higher Z score of weight, MI, and waist/height ratio and high serum cholesterol, LDL, TG, and low HDL were observed in obese children. Higher levels of serum lipocalin-2 and adipsin and lower IL-10 blood level were observed in the obese group in comparison with the normal weight children. Higher insulin resistance index was observed in the obese group, with positive correlation of HOMA-IR with the anthropometric measurements and lipocalin serum level, while negative correlation was observed between IL-10 and fasting insulin in obese children. CONCLUSION: Simple measurement of general and central adiposity markers and serum lipocalin-2 can predict insulin resistance in obese children while serum adipsin and IL-10 had no association with insulin resistance. Dove 2022-10-21 /pmc/articles/PMC9585482/ /pubmed/36276297 http://dx.doi.org/10.2147/DMSO.S377072 Text en © 2022 El Sehmawy et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research El Sehmawy, Asmaa A Diab, Fatma Elzhraa Ahmed Hassan, Donia Ahmed Mohammed, Doaa Sayed Gamal El Din Al Anany, Mona Eldesoky, Noha A Elamir, Reham Yousri Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children |
title | Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children |
title_full | Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children |
title_fullStr | Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children |
title_full_unstemmed | Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children |
title_short | Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children |
title_sort | utility of adipokines and il-10 in association with anthropometry in prediction of insulin resistance in obese children |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585482/ https://www.ncbi.nlm.nih.gov/pubmed/36276297 http://dx.doi.org/10.2147/DMSO.S377072 |
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