Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Loss-of-function mutations in the polycomb repressive complex 2 (PRC2) occur frequently in malignant peripheral nerve sheath tumor, an aggressive sarcoma that arises from NF1-deficient Schwann cells. To define the oncogenic mechanisms underlying PRC2 loss, we use engineered cells that dynamically re...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiyuan, Lou, Hannah E., Gopalan, Vishaka, Liu, Zhihui, Jafarah, Hilda M., Lei, Haiyan, Jones, Paige, Sayers, Carly M., Yohe, Marielle E., Chittiboina, Prashant, Widemann, Brigitte C., Thiele, Carol J., Kelly, Michael C., Hannenhalli, Sridhar, Shern, Jack F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585487/
https://www.ncbi.nlm.nih.gov/pubmed/36130486
http://dx.doi.org/10.1016/j.celrep.2022.111363

Ejemplares similares

Ejemplares similares