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The role of vitamin D in the onset and progression of diabetic retinopathy

Having a classical role in the regulation of calcium homeostasis in skeletal system, vitamin D has also been recognized as being involved in the activity of the immune system, as well as in the pathology of the visual analyzer. Thus, regarding the function of vitamin D in the eye, this is supported...

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Autores principales: Totolici, Geanina, Tiutiuca, Carmen, Jurja, Sanda, Tutunaru, Dana, Pătrașcu, Andra-Mădălina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Romanian Society of Ophthalmology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585492/
https://www.ncbi.nlm.nih.gov/pubmed/36349170
http://dx.doi.org/10.22336/rjo.2022.42
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author Totolici, Geanina
Tiutiuca, Carmen
Jurja, Sanda
Tutunaru, Dana
Pătrașcu, Andra-Mădălina
author_facet Totolici, Geanina
Tiutiuca, Carmen
Jurja, Sanda
Tutunaru, Dana
Pătrașcu, Andra-Mădălina
author_sort Totolici, Geanina
collection PubMed
description Having a classical role in the regulation of calcium homeostasis in skeletal system, vitamin D has also been recognized as being involved in the activity of the immune system, as well as in the pathology of the visual analyzer. Thus, regarding the function of vitamin D in the eye, this is supported by the identification of vitamin D receptors (VDR) in several structures of the eyeball, such as corneal epithelial and endothelial cells, ciliary body and retinal cells. One of the ophthalmological pathologies in which vitamin D plays an important role is diabetic retinopathy, both through its effects on the immune system (reduction of the pro-inflammatory cytokines - IL-1, IL-6, IL-012, TNF alpha, and stimulation of anti-inflammatory cytokines IL-10), as well as by reducing the level of vascular endothelial growth factor (VEGF) and thus inhibiting retinal neovascularization. Vitamin D demonstrates a protective role on the development and progression of diabetic retinopathy by reducing blood sugar, hypertension and atherosclerosis, but randomized studies are still needed to establish the direct causal relationship between the development of diabetic retinopathy and vitamin D levels.
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spelling pubmed-95854922022-11-07 The role of vitamin D in the onset and progression of diabetic retinopathy Totolici, Geanina Tiutiuca, Carmen Jurja, Sanda Tutunaru, Dana Pătrașcu, Andra-Mădălina Rom J Ophthalmol Reviews Having a classical role in the regulation of calcium homeostasis in skeletal system, vitamin D has also been recognized as being involved in the activity of the immune system, as well as in the pathology of the visual analyzer. Thus, regarding the function of vitamin D in the eye, this is supported by the identification of vitamin D receptors (VDR) in several structures of the eyeball, such as corneal epithelial and endothelial cells, ciliary body and retinal cells. One of the ophthalmological pathologies in which vitamin D plays an important role is diabetic retinopathy, both through its effects on the immune system (reduction of the pro-inflammatory cytokines - IL-1, IL-6, IL-012, TNF alpha, and stimulation of anti-inflammatory cytokines IL-10), as well as by reducing the level of vascular endothelial growth factor (VEGF) and thus inhibiting retinal neovascularization. Vitamin D demonstrates a protective role on the development and progression of diabetic retinopathy by reducing blood sugar, hypertension and atherosclerosis, but randomized studies are still needed to establish the direct causal relationship between the development of diabetic retinopathy and vitamin D levels. Romanian Society of Ophthalmology 2022 /pmc/articles/PMC9585492/ /pubmed/36349170 http://dx.doi.org/10.22336/rjo.2022.42 Text en © The Authors.Romanian Society of Ophthalmology https://creativecommons.org/licenses/by/2.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Totolici, Geanina
Tiutiuca, Carmen
Jurja, Sanda
Tutunaru, Dana
Pătrașcu, Andra-Mădălina
The role of vitamin D in the onset and progression of diabetic retinopathy
title The role of vitamin D in the onset and progression of diabetic retinopathy
title_full The role of vitamin D in the onset and progression of diabetic retinopathy
title_fullStr The role of vitamin D in the onset and progression of diabetic retinopathy
title_full_unstemmed The role of vitamin D in the onset and progression of diabetic retinopathy
title_short The role of vitamin D in the onset and progression of diabetic retinopathy
title_sort role of vitamin d in the onset and progression of diabetic retinopathy
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585492/
https://www.ncbi.nlm.nih.gov/pubmed/36349170
http://dx.doi.org/10.22336/rjo.2022.42
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