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The role of Anti-VEGF agents in treatment of neovascular glaucoma

Aim: The aim of this study was to show the efficacy of intravitreal treatment with Bevacizumab (Avastin) in patients with secondary neovascular glaucoma, in different stages of the disease. Method: A retrospective study was performed on 67 patients with neovascular glaucoma. The main parameters eval...

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Autores principales: Palfi (Salavat), Mădălina-Casiana, Șeclăman, Edward Paul, Barac, Ramona, Ungureanu, Emil, Iorgu, Gabriel, Artamonov, Andrada, Leuștean, Laurențiu, Borugă, Mădălina Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Romanian Society of Ophthalmology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585493/
https://www.ncbi.nlm.nih.gov/pubmed/36349171
http://dx.doi.org/10.22336/rjo.2022.41
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author Palfi (Salavat), Mădălina-Casiana
Șeclăman, Edward Paul
Barac, Ramona
Ungureanu, Emil
Iorgu, Gabriel
Artamonov, Andrada
Leuștean, Laurențiu
Borugă, Mădălina Veronica
author_facet Palfi (Salavat), Mădălina-Casiana
Șeclăman, Edward Paul
Barac, Ramona
Ungureanu, Emil
Iorgu, Gabriel
Artamonov, Andrada
Leuștean, Laurențiu
Borugă, Mădălina Veronica
author_sort Palfi (Salavat), Mădălina-Casiana
collection PubMed
description Aim: The aim of this study was to show the efficacy of intravitreal treatment with Bevacizumab (Avastin) in patients with secondary neovascular glaucoma, in different stages of the disease. Method: A retrospective study was performed on 67 patients with neovascular glaucoma. The main parameters evaluated were the patients’ history, slit lamp examination, visual acuity, ocular tonometry, fundus examination, gonioscopy, and visual field. Results: It was observed that the pathology had a preponderance in males of the 6th decade, with frequently unilateral damage. Patients were referred to an ophthalmologist when the diseases reached an advanced stage, usually when the visual acuity had no light perception and the intraocular pressure was over 45 mmHg. However, the treatment with Avastin intravitreal showed a good evolution, with regression of neovessels in the first 4-7 days and maintenance of intraocular pressure within normal limits in about 60% of cases, 3 months after injection. Conclusion: The most effective treatment in secondary neovascular glaucoma is the correct therapy of the main disease. The association of Avastin and laser photocoagulation leads to regression in iris and retinal neovessels. Abbreviations: anti-VEGF = anti-Vascular Endothelial Growth Factor, PDGF = Platelet Derived Growth Factor, bFGF = basic Fibroblast Growth Factor
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spelling pubmed-95854932022-11-07 The role of Anti-VEGF agents in treatment of neovascular glaucoma Palfi (Salavat), Mădălina-Casiana Șeclăman, Edward Paul Barac, Ramona Ungureanu, Emil Iorgu, Gabriel Artamonov, Andrada Leuștean, Laurențiu Borugă, Mădălina Veronica Rom J Ophthalmol Reviews Aim: The aim of this study was to show the efficacy of intravitreal treatment with Bevacizumab (Avastin) in patients with secondary neovascular glaucoma, in different stages of the disease. Method: A retrospective study was performed on 67 patients with neovascular glaucoma. The main parameters evaluated were the patients’ history, slit lamp examination, visual acuity, ocular tonometry, fundus examination, gonioscopy, and visual field. Results: It was observed that the pathology had a preponderance in males of the 6th decade, with frequently unilateral damage. Patients were referred to an ophthalmologist when the diseases reached an advanced stage, usually when the visual acuity had no light perception and the intraocular pressure was over 45 mmHg. However, the treatment with Avastin intravitreal showed a good evolution, with regression of neovessels in the first 4-7 days and maintenance of intraocular pressure within normal limits in about 60% of cases, 3 months after injection. Conclusion: The most effective treatment in secondary neovascular glaucoma is the correct therapy of the main disease. The association of Avastin and laser photocoagulation leads to regression in iris and retinal neovessels. Abbreviations: anti-VEGF = anti-Vascular Endothelial Growth Factor, PDGF = Platelet Derived Growth Factor, bFGF = basic Fibroblast Growth Factor Romanian Society of Ophthalmology 2022 /pmc/articles/PMC9585493/ /pubmed/36349171 http://dx.doi.org/10.22336/rjo.2022.41 Text en © The Authors.Romanian Society of Ophthalmology https://creativecommons.org/licenses/by/2.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Palfi (Salavat), Mădălina-Casiana
Șeclăman, Edward Paul
Barac, Ramona
Ungureanu, Emil
Iorgu, Gabriel
Artamonov, Andrada
Leuștean, Laurențiu
Borugă, Mădălina Veronica
The role of Anti-VEGF agents in treatment of neovascular glaucoma
title The role of Anti-VEGF agents in treatment of neovascular glaucoma
title_full The role of Anti-VEGF agents in treatment of neovascular glaucoma
title_fullStr The role of Anti-VEGF agents in treatment of neovascular glaucoma
title_full_unstemmed The role of Anti-VEGF agents in treatment of neovascular glaucoma
title_short The role of Anti-VEGF agents in treatment of neovascular glaucoma
title_sort role of anti-vegf agents in treatment of neovascular glaucoma
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585493/
https://www.ncbi.nlm.nih.gov/pubmed/36349171
http://dx.doi.org/10.22336/rjo.2022.41
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