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Investigation of Acid–Base Catalysis in Halimadienyl Diphosphate Synthase Involved in Mycobacterium tuberculosis Virulence

[Image: see text] The devastating human pathogenMycobacterium tuberculosis (Mtb) is able to parasitize phagosomal compartments within alveolar macrophage cells due, in part, to the activity of its cell-surface lipids. Prominent among these is 1-tuberculosinyl-adenosine (1-TbAd), a derivative of the...

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Detalles Bibliográficos
Autores principales: Lemke, Cody, Roach, Kristin, Ortega, Teresa, Tantillo, Dean J., Siegel, Justin B., Peters, Reuben J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585517/
https://www.ncbi.nlm.nih.gov/pubmed/36281298
http://dx.doi.org/10.1021/acsbiomedchemau.2c00023