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Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA(1) antibody associated with mRNA COVID-19 vaccination: a case report
Newly-diagnosed or relapses of immunoglobulin A nephropathy (IgAN) have been associated with COVID-19 vaccination in the literature. Most reported cases were mild clinical diseases characterized by microscopic haematuria and do not require dialysis treatment. This current case report describes a 55-...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585566/ https://www.ncbi.nlm.nih.gov/pubmed/36262058 http://dx.doi.org/10.1177/03000605221129674 |
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author | Chen, Yun-Sung Yang, Cheng-Wen Tsai, Chien-Chen Ang, Min-De Chou, San-Fang Chiang, Wen-Chih Chiu, Yen-Ling |
author_facet | Chen, Yun-Sung Yang, Cheng-Wen Tsai, Chien-Chen Ang, Min-De Chou, San-Fang Chiang, Wen-Chih Chiu, Yen-Ling |
author_sort | Chen, Yun-Sung |
collection | PubMed |
description | Newly-diagnosed or relapses of immunoglobulin A nephropathy (IgAN) have been associated with COVID-19 vaccination in the literature. Most reported cases were mild clinical diseases characterized by microscopic haematuria and do not require dialysis treatment. This current case report describes a 55-year-old male patient that presented to the emergency department with acute kidney injury after receiving the first dose of the mRNA-1273 COVID-19 vaccine. After admission, his renal function deteriorated rapidly, and then he developed uraemic encephalopathy. He underwent emergency haemodialysis with a rapid improvement in his mental status. Renal biopsy showed newly-diagnosed IgA nephropathy along with markedly elevated plasma level of galactose-deficient-IgA(1) (Gd-IgA(1)) antibody. The patient did not receive immunosuppressive treatment and is now dialysis-free. Immune activation is considered an essential factor in developing or exacerbating IgAN following COVID-19 vaccination. This current case report demonstrates that elevated Gd-IgA(1) antibody may be the potential mechanistic link between COVID-19 vaccination and IgAN. |
format | Online Article Text |
id | pubmed-9585566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-95855662022-10-22 Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA(1) antibody associated with mRNA COVID-19 vaccination: a case report Chen, Yun-Sung Yang, Cheng-Wen Tsai, Chien-Chen Ang, Min-De Chou, San-Fang Chiang, Wen-Chih Chiu, Yen-Ling J Int Med Res Case Reports Newly-diagnosed or relapses of immunoglobulin A nephropathy (IgAN) have been associated with COVID-19 vaccination in the literature. Most reported cases were mild clinical diseases characterized by microscopic haematuria and do not require dialysis treatment. This current case report describes a 55-year-old male patient that presented to the emergency department with acute kidney injury after receiving the first dose of the mRNA-1273 COVID-19 vaccine. After admission, his renal function deteriorated rapidly, and then he developed uraemic encephalopathy. He underwent emergency haemodialysis with a rapid improvement in his mental status. Renal biopsy showed newly-diagnosed IgA nephropathy along with markedly elevated plasma level of galactose-deficient-IgA(1) (Gd-IgA(1)) antibody. The patient did not receive immunosuppressive treatment and is now dialysis-free. Immune activation is considered an essential factor in developing or exacerbating IgAN following COVID-19 vaccination. This current case report demonstrates that elevated Gd-IgA(1) antibody may be the potential mechanistic link between COVID-19 vaccination and IgAN. SAGE Publications 2022-10-19 /pmc/articles/PMC9585566/ /pubmed/36262058 http://dx.doi.org/10.1177/03000605221129674 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Reports Chen, Yun-Sung Yang, Cheng-Wen Tsai, Chien-Chen Ang, Min-De Chou, San-Fang Chiang, Wen-Chih Chiu, Yen-Ling Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA(1) antibody associated with mRNA COVID-19 vaccination: a case report |
title | Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA(1) antibody associated with mRNA COVID-19 vaccination: a case report |
title_full | Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA(1) antibody associated with mRNA COVID-19 vaccination: a case report |
title_fullStr | Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA(1) antibody associated with mRNA COVID-19 vaccination: a case report |
title_full_unstemmed | Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA(1) antibody associated with mRNA COVID-19 vaccination: a case report |
title_short | Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA(1) antibody associated with mRNA COVID-19 vaccination: a case report |
title_sort | newly-diagnosed immunoglobulin a nephropathy with increased plasma galactose-deficient-iga(1) antibody associated with mrna covid-19 vaccination: a case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585566/ https://www.ncbi.nlm.nih.gov/pubmed/36262058 http://dx.doi.org/10.1177/03000605221129674 |
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