Discovery of Small-Molecule Allosteric Inhibitors of PfATC as Antimalarials

[Image: see text] The discovery and development of new drugs against malaria remain urgent. Aspartate transcarbamoylase (ATC) has been suggested to be a promising target for antimalarial drug development. Here, we describe a series of small-molecule inhibitors of P. falciparum ATC with low nanomolar...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Zhang, Bidong, Krüger, Arne, Du, Xiaochen, Visser, Lidia, Dömling, Alexander S S, Wrenger, Carsten, Groves, Matthew R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585585/
https://www.ncbi.nlm.nih.gov/pubmed/36195578
http://dx.doi.org/10.1021/jacs.2c08128

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