Comparative Photoaffinity Profiling of Omega-3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages

[Image: see text] The fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3) is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the biological effect of DHA are poorly understood. Here, we report the design, synthesis, and application of a complementary pa...

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Detalles Bibliográficos
Autores principales: Gagestein, Berend, von Hegedus, Johannes H., Kwekkeboom, Joanneke C., Heijink, Marieke, Blomberg, Niek, van der Wel, Tom, Florea, Bogdan I., van den Elst, Hans, Wals, Kim, Overkleeft, Herman S., Giera, Martin, Toes, René E. M., Ioan-Facsinay, Andreea, van der Stelt, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585591/
https://www.ncbi.nlm.nih.gov/pubmed/36197299
http://dx.doi.org/10.1021/jacs.2c06827

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