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Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids

Children with autism spectrum disorder (ASD) experience gastrointestinal (GI) issues more frequently and severely than children who are typically developing (TD). The connections between gastrointestinal problems, microbiota, and short-chain fatty acids (SCFAs) in ASD are still being debated. We enr...

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Autores principales: Deng, Wenlin, Wang, Siqi, Li, Fang, Wang, Fang, Xing, Yi Pei, Li, Yongchun, Lv, Ying, Ke, Haoran, Li, Zitong, Lv, Pin Jing, Hao, Hu, Chen, Ye, Xiao, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585932/
https://www.ncbi.nlm.nih.gov/pubmed/36274684
http://dx.doi.org/10.3389/fmicb.2022.1000419
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author Deng, Wenlin
Wang, Siqi
Li, Fang
Wang, Fang
Xing, Yi Pei
Li, Yongchun
Lv, Ying
Ke, Haoran
Li, Zitong
Lv, Pin Jing
Hao, Hu
Chen, Ye
Xiao, Xin
author_facet Deng, Wenlin
Wang, Siqi
Li, Fang
Wang, Fang
Xing, Yi Pei
Li, Yongchun
Lv, Ying
Ke, Haoran
Li, Zitong
Lv, Pin Jing
Hao, Hu
Chen, Ye
Xiao, Xin
author_sort Deng, Wenlin
collection PubMed
description Children with autism spectrum disorder (ASD) experience gastrointestinal (GI) issues more frequently and severely than children who are typically developing (TD). The connections between gastrointestinal problems, microbiota, and short-chain fatty acids (SCFAs) in ASD are still being debated. We enrolled 90 children, 45 of whom were diagnosed with ASD, and examined the impact of GI disorders on ASD. The six-item GI Severity Index questionnaire was used to evaluate gastrointestinal symptoms, while the Social Responsiveness Scale was used to evaluate autism symptoms. Further, the Children’s Sleep Habits Questionnaire and the Children’s Eating Behavior Questionnaire are used to assess sleep and eating disorders in children. We assessed fecal microbiota by 16S rRNA gene sequencing, and SCFA concentrations by gas chromatography/mass spectrometry. The results revealed that children with ASD exhibited a high rate of gastrointestinal issues (78%), as well as higher rates of social impairment and poor sleeping habits, compared to TD children. However, GI disturbances have a minor impact on autism. In addition, the levels of propionic acid, butyric acid, and valeric acid were significantly higher in the ASD group. Besides, the ASD, TD, and GI subgroups possessed distinct microbiome profiles. These findings suggest that gastrointestinal disturbances have no discernible effect on the core symptoms of autism. Although autism may not cause an increase in GI symptoms directly, alterations in metabolites, such as SCFAs, may cause GI symptoms.
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spelling pubmed-95859322022-10-22 Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids Deng, Wenlin Wang, Siqi Li, Fang Wang, Fang Xing, Yi Pei Li, Yongchun Lv, Ying Ke, Haoran Li, Zitong Lv, Pin Jing Hao, Hu Chen, Ye Xiao, Xin Front Microbiol Microbiology Children with autism spectrum disorder (ASD) experience gastrointestinal (GI) issues more frequently and severely than children who are typically developing (TD). The connections between gastrointestinal problems, microbiota, and short-chain fatty acids (SCFAs) in ASD are still being debated. We enrolled 90 children, 45 of whom were diagnosed with ASD, and examined the impact of GI disorders on ASD. The six-item GI Severity Index questionnaire was used to evaluate gastrointestinal symptoms, while the Social Responsiveness Scale was used to evaluate autism symptoms. Further, the Children’s Sleep Habits Questionnaire and the Children’s Eating Behavior Questionnaire are used to assess sleep and eating disorders in children. We assessed fecal microbiota by 16S rRNA gene sequencing, and SCFA concentrations by gas chromatography/mass spectrometry. The results revealed that children with ASD exhibited a high rate of gastrointestinal issues (78%), as well as higher rates of social impairment and poor sleeping habits, compared to TD children. However, GI disturbances have a minor impact on autism. In addition, the levels of propionic acid, butyric acid, and valeric acid were significantly higher in the ASD group. Besides, the ASD, TD, and GI subgroups possessed distinct microbiome profiles. These findings suggest that gastrointestinal disturbances have no discernible effect on the core symptoms of autism. Although autism may not cause an increase in GI symptoms directly, alterations in metabolites, such as SCFAs, may cause GI symptoms. Frontiers Media S.A. 2022-10-07 /pmc/articles/PMC9585932/ /pubmed/36274684 http://dx.doi.org/10.3389/fmicb.2022.1000419 Text en Copyright © 2022 Deng, Wang, Li, Wang, Xing, Li, Lv, Ke, Li, Lv, Hao, Chen and Xiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Deng, Wenlin
Wang, Siqi
Li, Fang
Wang, Fang
Xing, Yi Pei
Li, Yongchun
Lv, Ying
Ke, Haoran
Li, Zitong
Lv, Pin Jing
Hao, Hu
Chen, Ye
Xiao, Xin
Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids
title Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids
title_full Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids
title_fullStr Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids
title_full_unstemmed Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids
title_short Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids
title_sort gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585932/
https://www.ncbi.nlm.nih.gov/pubmed/36274684
http://dx.doi.org/10.3389/fmicb.2022.1000419
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