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Unveiling a family of spiro-β-lactams with anti-HIV and antiplasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates

The molecular architecture of spirocyclic compounds has been widely explored within the medicinal chemistry field to obtain new compounds with singular three-dimensional pharmacophoric features and improved bioactivity. Herein, the synthesis of 68 new spirocyclopentene-β-lactams is described, result...

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Detalles Bibliográficos
Autores principales:	Alves, Américo J. S., Alves, Nuno G., Bártolo, Inês, Fontinha, Diana, Caetano, Soraia, Prudêncio, Miguel, Taveira, Nuno, Pinho e Melo, Teresa M. V. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585939/ https://www.ncbi.nlm.nih.gov/pubmed/36277353 http://dx.doi.org/10.3389/fchem.2022.1017250

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