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An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65

RPE65 retinol isomerase is an indispensable player in the visual cycle between the vertebrate retina and RPE. Although membrane association is critical for RPE65 function, its mechanism is not clear. Residues 107–125 are believed to interact with membranes but are unresolved in all RPE65 crystal str...

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Detalles Bibliográficos
Autores principales:	Uppal, Sheetal, Liu, Tingting, Galvan, Emily, Gomez, Fatima, Tittley, Tishina, Poliakov, Eugenia, Gentleman, Susan, Redmond, T Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585964/ https://www.ncbi.nlm.nih.gov/pubmed/36265895 http://dx.doi.org/10.26508/lsa.202201546

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