(18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy

Growing teratoma syndrome (GTS) is a condition in which poorly differentiated cells in a mixed-germ cell tumor (GCT) regress after chemotherapy, and the number of well-differentiated components increases. A 60-year-old man had an 8.0 cm mediastinal tumor with strong (18)F-fluorodeoxyglucose (FDG) up...

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Detalles Bibliográficos
Autores principales: Sasahara, Mihoko, Abe, Takashi, Otomi, Yoichi, Abe, Yumi, Toba, Hiroaki, Shinya, Takayoshi, Otsuka, Hideki, Harada, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586005/
https://www.ncbi.nlm.nih.gov/pubmed/36268930
http://dx.doi.org/10.4274/mirt.galenos.2021.54775
Descripción
Sumario:Growing teratoma syndrome (GTS) is a condition in which poorly differentiated cells in a mixed-germ cell tumor (GCT) regress after chemotherapy, and the number of well-differentiated components increases. A 60-year-old man had an 8.0 cm mediastinal tumor with strong (18)F-fluorodeoxyglucose (FDG) uptake [maximum standardized uptake value (SUV(max)): 9.2], which was diagnosed as a GCT. After chemotherapy, serum alpha fetoprotein, beta-human chorionic gonadotropin, and tumor (18)F-FDG uptake decreased (SUV(max): 3.9), but the tumor volume increased. The tumor was completely resected, and pathology confirmed the diagnosis of GTS. (18)F-FDG positron emission tomography after chemotherapy reflects the proliferation of highly differentiated tumor components with poor (18)F-FDG uptake.

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