(18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy

Growing teratoma syndrome (GTS) is a condition in which poorly differentiated cells in a mixed-germ cell tumor (GCT) regress after chemotherapy, and the number of well-differentiated components increases. A 60-year-old man had an 8.0 cm mediastinal tumor with strong (18)F-fluorodeoxyglucose (FDG) up...

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Autores principales: Sasahara, Mihoko, Abe, Takashi, Otomi, Yoichi, Abe, Yumi, Toba, Hiroaki, Shinya, Takayoshi, Otsuka, Hideki, Harada, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2022
Materias:
Interesting Image
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586005/
https://www.ncbi.nlm.nih.gov/pubmed/36268930
http://dx.doi.org/10.4274/mirt.galenos.2021.54775
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author Sasahara, Mihoko
Abe, Takashi
Otomi, Yoichi
Abe, Yumi
Toba, Hiroaki
Shinya, Takayoshi
Otsuka, Hideki
Harada, Masafumi
author_facet Sasahara, Mihoko
Abe, Takashi
Otomi, Yoichi
Abe, Yumi
Toba, Hiroaki
Shinya, Takayoshi
Otsuka, Hideki
Harada, Masafumi
author_sort Sasahara, Mihoko
collection PubMed
description Growing teratoma syndrome (GTS) is a condition in which poorly differentiated cells in a mixed-germ cell tumor (GCT) regress after chemotherapy, and the number of well-differentiated components increases. A 60-year-old man had an 8.0 cm mediastinal tumor with strong (18)F-fluorodeoxyglucose (FDG) uptake [maximum standardized uptake value (SUV(max)): 9.2], which was diagnosed as a GCT. After chemotherapy, serum alpha fetoprotein, beta-human chorionic gonadotropin, and tumor (18)F-FDG uptake decreased (SUV(max): 3.9), but the tumor volume increased. The tumor was completely resected, and pathology confirmed the diagnosis of GTS. (18)F-FDG positron emission tomography after chemotherapy reflects the proliferation of highly differentiated tumor components with poor (18)F-FDG uptake.
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spelling pubmed-95860052022-10-26 (18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy Sasahara, Mihoko Abe, Takashi Otomi, Yoichi Abe, Yumi Toba, Hiroaki Shinya, Takayoshi Otsuka, Hideki Harada, Masafumi Mol Imaging Radionucl Ther Interesting Image Growing teratoma syndrome (GTS) is a condition in which poorly differentiated cells in a mixed-germ cell tumor (GCT) regress after chemotherapy, and the number of well-differentiated components increases. A 60-year-old man had an 8.0 cm mediastinal tumor with strong (18)F-fluorodeoxyglucose (FDG) uptake [maximum standardized uptake value (SUV(max)): 9.2], which was diagnosed as a GCT. After chemotherapy, serum alpha fetoprotein, beta-human chorionic gonadotropin, and tumor (18)F-FDG uptake decreased (SUV(max): 3.9), but the tumor volume increased. The tumor was completely resected, and pathology confirmed the diagnosis of GTS. (18)F-FDG positron emission tomography after chemotherapy reflects the proliferation of highly differentiated tumor components with poor (18)F-FDG uptake. Galenos Publishing 2022-10 2022-10-19 /pmc/articles/PMC9586005/ /pubmed/36268930 http://dx.doi.org/10.4274/mirt.galenos.2021.54775 Text en ©Copyright 2022 by Turkish Society of Nuclear Medicine | Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Interesting Image
Sasahara, Mihoko
Abe, Takashi
Otomi, Yoichi
Abe, Yumi
Toba, Hiroaki
Shinya, Takayoshi
Otsuka, Hideki
Harada, Masafumi
(18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy
title (18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy
title_full (18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy
title_fullStr (18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy
title_full_unstemmed (18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy
title_short (18)F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy
title_sort (18)f-fdg pet/ct showing rare mediastinal growing teratoma syndrome following chemotherapy
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586005/
https://www.ncbi.nlm.nih.gov/pubmed/36268930
http://dx.doi.org/10.4274/mirt.galenos.2021.54775
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