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Characterization of the Retinal Microvasculature and FAZ Changes in Ischemic Stroke and Its Different Types

PURPOSE: This study aimed to assess morphological changes in the retinal microvasculature and foveal avascular zone (FAZ) in patients with ischemic stroke and its different subtypes. METHODS: Thirty-three patients with ischemic stroke (14 with nonlacunar infarction and 19 with lacunar infarction) an...

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Autores principales: Duan, Hongyu, Xie, Jianyang, Zhou, Yifan, Zhang, Hui, Liu, Yiyun, Tang, Chuhao, Zhao, Yitian, Qi, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586132/
https://www.ncbi.nlm.nih.gov/pubmed/36239966
http://dx.doi.org/10.1167/tvst.11.10.21
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author Duan, Hongyu
Xie, Jianyang
Zhou, Yifan
Zhang, Hui
Liu, Yiyun
Tang, Chuhao
Zhao, Yitian
Qi, Hong
author_facet Duan, Hongyu
Xie, Jianyang
Zhou, Yifan
Zhang, Hui
Liu, Yiyun
Tang, Chuhao
Zhao, Yitian
Qi, Hong
author_sort Duan, Hongyu
collection PubMed
description PURPOSE: This study aimed to assess morphological changes in the retinal microvasculature and foveal avascular zone (FAZ) in patients with ischemic stroke and its different subtypes. METHODS: Thirty-three patients with ischemic stroke (14 with nonlacunar infarction and 19 with lacunar infarction) and 27 control participants were enrolled in this study. Based on optical coherence tomography angiography (OCTA), three vascular parameters, including vascular area density, vascular fractal dimension (VFD), and vascular orientation distribution (VOD), and four FAZ-related parameters, including FAZ area, FAZ axis ratio (FAR), FAZ circularity (FC), and FAZ roundness, in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were extracted and analyzed. RESULTS: Logistic regression results showed that worse best-corrected visual acuity (odds ratio [OR], 0.21), higher FAR (OR, 2.77) and lower FC (OR, 0.36) of the DCP were associated with ischemic stroke. Furthermore, lower VOD of the SCP was significantly associated with lacunar infarction compared with nonlacunar infarction. CONCLUSIONS: Our study shows that the FAR and FC of the DCP may be potential biomarkers of ischemic stroke. Moreover, we demonstrated that OCT showed specific damage patterns in retinal microvascular and macular morphology in different subtypes of ischemic stroke. TRANSLATIONAL RELEVANCE: This work lays the foundation for the pathophysiological characteristics of cerebrovascular diseases assisted by retinal imaging and artificial intelligence.
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spelling pubmed-95861322022-10-22 Characterization of the Retinal Microvasculature and FAZ Changes in Ischemic Stroke and Its Different Types Duan, Hongyu Xie, Jianyang Zhou, Yifan Zhang, Hui Liu, Yiyun Tang, Chuhao Zhao, Yitian Qi, Hong Transl Vis Sci Technol Artificial Intelligence PURPOSE: This study aimed to assess morphological changes in the retinal microvasculature and foveal avascular zone (FAZ) in patients with ischemic stroke and its different subtypes. METHODS: Thirty-three patients with ischemic stroke (14 with nonlacunar infarction and 19 with lacunar infarction) and 27 control participants were enrolled in this study. Based on optical coherence tomography angiography (OCTA), three vascular parameters, including vascular area density, vascular fractal dimension (VFD), and vascular orientation distribution (VOD), and four FAZ-related parameters, including FAZ area, FAZ axis ratio (FAR), FAZ circularity (FC), and FAZ roundness, in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were extracted and analyzed. RESULTS: Logistic regression results showed that worse best-corrected visual acuity (odds ratio [OR], 0.21), higher FAR (OR, 2.77) and lower FC (OR, 0.36) of the DCP were associated with ischemic stroke. Furthermore, lower VOD of the SCP was significantly associated with lacunar infarction compared with nonlacunar infarction. CONCLUSIONS: Our study shows that the FAR and FC of the DCP may be potential biomarkers of ischemic stroke. Moreover, we demonstrated that OCT showed specific damage patterns in retinal microvascular and macular morphology in different subtypes of ischemic stroke. TRANSLATIONAL RELEVANCE: This work lays the foundation for the pathophysiological characteristics of cerebrovascular diseases assisted by retinal imaging and artificial intelligence. The Association for Research in Vision and Ophthalmology 2022-10-14 /pmc/articles/PMC9586132/ /pubmed/36239966 http://dx.doi.org/10.1167/tvst.11.10.21 Text en Copyright 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Artificial Intelligence
Duan, Hongyu
Xie, Jianyang
Zhou, Yifan
Zhang, Hui
Liu, Yiyun
Tang, Chuhao
Zhao, Yitian
Qi, Hong
Characterization of the Retinal Microvasculature and FAZ Changes in Ischemic Stroke and Its Different Types
title Characterization of the Retinal Microvasculature and FAZ Changes in Ischemic Stroke and Its Different Types
title_full Characterization of the Retinal Microvasculature and FAZ Changes in Ischemic Stroke and Its Different Types
title_fullStr Characterization of the Retinal Microvasculature and FAZ Changes in Ischemic Stroke and Its Different Types
title_full_unstemmed Characterization of the Retinal Microvasculature and FAZ Changes in Ischemic Stroke and Its Different Types
title_short Characterization of the Retinal Microvasculature and FAZ Changes in Ischemic Stroke and Its Different Types
title_sort characterization of the retinal microvasculature and faz changes in ischemic stroke and its different types
topic Artificial Intelligence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586132/
https://www.ncbi.nlm.nih.gov/pubmed/36239966
http://dx.doi.org/10.1167/tvst.11.10.21
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