Cargando…
Implications of Neural Plasticity in Retinal Prosthesis
Retinal degenerative diseases such as retinitis pigmentosa cause a progressive loss of photoreceptors that eventually prevents the affected person from perceiving visual sensations. The absence of a visual input produces a neural rewiring cascade that propagates along the visual system. This remodel...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586139/ https://www.ncbi.nlm.nih.gov/pubmed/36251317 http://dx.doi.org/10.1167/iovs.63.11.11 |
_version_ | 1784813633539145728 |
---|---|
author | Caravaca-Rodriguez, Daniel Gaytan, Susana P. Suaning, Gregg J. Barriga-Rivera, Alejandro |
author_facet | Caravaca-Rodriguez, Daniel Gaytan, Susana P. Suaning, Gregg J. Barriga-Rivera, Alejandro |
author_sort | Caravaca-Rodriguez, Daniel |
collection | PubMed |
description | Retinal degenerative diseases such as retinitis pigmentosa cause a progressive loss of photoreceptors that eventually prevents the affected person from perceiving visual sensations. The absence of a visual input produces a neural rewiring cascade that propagates along the visual system. This remodeling occurs first within the retina. Then, subsequent neuroplastic changes take place at higher visual centers in the brain, produced by either the abnormal neural encoding of the visual inputs delivered by the diseased retina or as the result of an adaptation to visual deprivation. While retinal implants can activate the surviving retinal neurons by delivering electric current, the unselective activation patterns of the different neural populations that exist in the retinal layers differ substantially from those in physiologic vision. Therefore, artificially induced neural patterns are being delivered to a brain that has already undergone important neural reconnections. Whether or not the modulation of this neural rewiring can improve the performance for retinal prostheses remains a critical question whose answer may be the enabler of improved functional artificial vision and more personalized neurorehabilitation strategies. |
format | Online Article Text |
id | pubmed-9586139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-95861392022-10-22 Implications of Neural Plasticity in Retinal Prosthesis Caravaca-Rodriguez, Daniel Gaytan, Susana P. Suaning, Gregg J. Barriga-Rivera, Alejandro Invest Ophthalmol Vis Sci Review Retinal degenerative diseases such as retinitis pigmentosa cause a progressive loss of photoreceptors that eventually prevents the affected person from perceiving visual sensations. The absence of a visual input produces a neural rewiring cascade that propagates along the visual system. This remodeling occurs first within the retina. Then, subsequent neuroplastic changes take place at higher visual centers in the brain, produced by either the abnormal neural encoding of the visual inputs delivered by the diseased retina or as the result of an adaptation to visual deprivation. While retinal implants can activate the surviving retinal neurons by delivering electric current, the unselective activation patterns of the different neural populations that exist in the retinal layers differ substantially from those in physiologic vision. Therefore, artificially induced neural patterns are being delivered to a brain that has already undergone important neural reconnections. Whether or not the modulation of this neural rewiring can improve the performance for retinal prostheses remains a critical question whose answer may be the enabler of improved functional artificial vision and more personalized neurorehabilitation strategies. The Association for Research in Vision and Ophthalmology 2022-10-17 /pmc/articles/PMC9586139/ /pubmed/36251317 http://dx.doi.org/10.1167/iovs.63.11.11 Text en Copyright 2022 The Authors https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Review Caravaca-Rodriguez, Daniel Gaytan, Susana P. Suaning, Gregg J. Barriga-Rivera, Alejandro Implications of Neural Plasticity in Retinal Prosthesis |
title | Implications of Neural Plasticity in Retinal Prosthesis |
title_full | Implications of Neural Plasticity in Retinal Prosthesis |
title_fullStr | Implications of Neural Plasticity in Retinal Prosthesis |
title_full_unstemmed | Implications of Neural Plasticity in Retinal Prosthesis |
title_short | Implications of Neural Plasticity in Retinal Prosthesis |
title_sort | implications of neural plasticity in retinal prosthesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586139/ https://www.ncbi.nlm.nih.gov/pubmed/36251317 http://dx.doi.org/10.1167/iovs.63.11.11 |
work_keys_str_mv | AT caravacarodriguezdaniel implicationsofneuralplasticityinretinalprosthesis AT gaytansusanap implicationsofneuralplasticityinretinalprosthesis AT suaninggreggj implicationsofneuralplasticityinretinalprosthesis AT barrigariveraalejandro implicationsofneuralplasticityinretinalprosthesis |