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The full activation mechanism of the adenosine A(1) receptor revealed by GaMD and Su-GaMD simulations

The full activation process of G protein–coupled receptor (GPCR) plays an important role in cellular signal transduction. However, it remains challenging to simulate the whole process in which the GPCR is recognized and activated by a ligand and then couples to the G protein on a reasonable simulati...

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Detalles Bibliográficos
Autores principales: Li, Yang, Sun, Jixue, Li, Dongmei, Lin, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586258/
https://www.ncbi.nlm.nih.gov/pubmed/36215480
http://dx.doi.org/10.1073/pnas.2203702119