Cargando…
The full activation mechanism of the adenosine A(1) receptor revealed by GaMD and Su-GaMD simulations
The full activation process of G protein–coupled receptor (GPCR) plays an important role in cellular signal transduction. However, it remains challenging to simulate the whole process in which the GPCR is recognized and activated by a ligand and then couples to the G protein on a reasonable simulati...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586258/ https://www.ncbi.nlm.nih.gov/pubmed/36215480 http://dx.doi.org/10.1073/pnas.2203702119 |