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Convergent regulation of Ca(V)1.2 channels by direct phosphorylation and by the small GTPase RAD in the cardiac fight-or-flight response
The L-type calcium currents conducted by the cardiac Ca(V)1.2 calcium channel initiate excitation–contraction coupling and serve as a key regulator of heart rate, rhythm, and force of contraction. Ca(V)1.2 is regulated by β-adrenergic/protein kinase A (PKA)-mediated protein phosphorylation, proteoly...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586275/ https://www.ncbi.nlm.nih.gov/pubmed/36215501 http://dx.doi.org/10.1073/pnas.2208533119 |