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The unstructured linker of Mlh1 contains a motif required for endonuclease function which is mutated in cancers

Eukaryotic DNA mismatch repair (MMR) depends on recruitment of the Mlh1-Pms1 endonuclease (human MLH1-PMS2) to mispaired DNA. Both Mlh1 and Pms1 contain a long unstructured linker that connects the N- and carboxyl-terminal domains. Here, we demonstrated the Mlh1 linker contains a conserved motif (Sa...

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Detalles Bibliográficos
Autores principales:	Torres, Kendall A., Calil, Felipe A., Zhou, Ann L., DuPrie, Matthew L., Putnam, Christopher D., Kolodner, Richard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586283/ https://www.ncbi.nlm.nih.gov/pubmed/36215471 http://dx.doi.org/10.1073/pnas.2212870119

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