HIRA loss transforms FH-deficient cells

Fumarate hydratase (FH) is a mitochondrial enzyme that catalyzes the reversible hydration of fumarate to malate in the tricarboxylic acid (TCA) cycle. Germline mutations of FH lead to hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a cancer syndrome characterized by a highly aggressive f...

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Detalles Bibliográficos
Autores principales: Valcarcel-Jimenez, Lorea, Rogerson, Connor, Yong, Cissy, Schmidt, Christina, Yang, Ming, Cremades-Rodelgo, Monica, Harle, Victoria, Offord, Victoria, Wong, Kim, Mora, Ariane, Speed, Alyson, Caraffini, Veronica, Tran, Maxine Gia Binh, Maher, Eamonn R., Stewart, Grant D., Vanharanta, Sakari, Adams, David J., Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586478/
https://www.ncbi.nlm.nih.gov/pubmed/36269833
http://dx.doi.org/10.1126/sciadv.abq8297

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